Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dynamics of brain-derived proteins in cerebrospinal fluid
Autore:
Reiber, H;
Indirizzi:
Univ Gottingen, Neurol Klin, Neurochem Lab, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 Lab, D-37075 Gottingen, Germany
Titolo Testata:
CLINICA CHIMICA ACTA
fascicolo: 2, volume: 310, anno: 2001,
pagine: 173 - 186
SICI:
0009-8981(20010820)310:2<173:DOBPIC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-TRACE PROTEIN; PROSTAGLANDIN-D SYNTHASE; NEURON-SPECIFIC ENOLASE; INTERCELLULAR-ADHESION MOLECULE-1; CREUTZFELDT-JAKOB-DISEASE; CENTRAL NERVOUS-SYSTEM; NEUROLOGICAL DISEASES; CHOROID-PLEXUS; S-100 PROTEIN; MESSENGER-RNA;
Keywords:
cerebrospinal fluid (CSF); CSF flow; blood-CSF barrier function; Tau protein; S-100 protein; neuron-specific enolase (NSE); beta-trace protein (prostaglandin D synthase); cystatin C; transthyretin; soluble intercellular adhesion molecule (s-ICAM); carcinoembryonic antigen (CEA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Reiber, H Univ Gottingen, Neurol Klin, Neurochem Lab, Robert Koch Str 40, D-37075 Gottingen, Germany Univ Gottingen Robert Koch Str 40 Gottingen Germany D-37075 any
Citazione:
H. Reiber, "Dynamics of brain-derived proteins in cerebrospinal fluid", CLIN CHIM A, 310(2), 2001, pp. 173-186

Abstract

Background: The recent theory of blood-cerebrospinal fluid (CSF) barrier function and dysfunction connects molecular flux and CSF flow rate. A reduced CSF flow rate is sufficient to account for the observed hyperbolic relation between different blood-derived protein concentrations in CSF in cases of a blood-CSF barrier dysfunction. Methods: The dynamics of brain-derived proteins in CSF are investigated with reference to the CSF flow rate measured by CSF/serum albumin concentration quotient. Results: Proteins from neurons or glial cells, tau protein, neuron-specific enolase, S-100 protein, allenter CSF primarily in the ventricular and cisternal space. Their concentration between normal ventricular and lumbar CSF is decreasing (in contrast to blood-derived proteins), and in the case of pathologically decreasing CSF flow rate, the concentration in lumbar CSF remains invariantly constant. Concentrations of the primarily leptomeningeal proteins, P-trace protein and cystatin C, increase between normal ventricular and lumbar CSF, and in the case of pathologically decreased CSF flow rate they increase linearly in lumbar CSF (concentrations of blood-derived proteins increase non-linearly). Conclusions: A satisfactory physiological explanation can now be given for the dynamics of proteins in CSF consisting of both brain- and blood-derived fractions (transthyretin, soluble intercellular adhesion molecule (s-ICAM)), as well as the disputed decrease of leptomeningeal protein concentrations (P-trace protein, cystatin C) in cases of bacterial meningitis is also explained. The biophysical treatment of dynamics in the ventricular and lumbar CSF extends the new theory and shows that CSF flow rate is the most relevant parameter for understanding the pathological changes of both blood- and brain-derived proteins in CSF. The impact on diagnosis of neuro-degenerative diseases is discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/02/20 alle ore 17:44:31