Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Intracellular transport of MHC class II and associated invariant chain in antigen presenting cells from AP-3-deficient mocha mice
Autore:
Sevilla, LM; Richter, SS; Miller, J;
Indirizzi:
Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 enet & Cell Biol, Chicago, IL 60637 USA Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 enet & Cell Biol, Chicago, IL 60637 USA
Titolo Testata:
CELLULAR IMMUNOLOGY
fascicolo: 2, volume: 210, anno: 2001,
pagine: 143 - 153
SICI:
0008-8749(20010615)210:2<143:ITOMCI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-LYMPHOBLASTOID-CELLS; LYSOSOMAL MEMBRANE-GLYCOPROTEINS; PEPTIDE-LOADING COMPARTMENTS; GOLGI NETWORK LOCALIZATION; SPLEEN DENDRITIC CELLS; AP-3 ADAPTER COMPLEX; CYTOPLASMIC TAIL; SORTING SIGNALS; PROTEIN COMPLEX; HLA-DM;
Keywords:
antigen presentation; MHC class II; invariant chain; adaptor proteins; adaptor protein-3; dileucine motifs; endosomal sorting;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
103
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, J Univ Chicago, Dept Mol Genet & Cell Biol, 920 E 58th St, Chicago, IL 60637USA Univ Chicago 920 E 58th St Chicago IL USA 60637 ago, IL 60637USA
Citazione:
L.M. Sevilla et al., "Intracellular transport of MHC class II and associated invariant chain in antigen presenting cells from AP-3-deficient mocha mice", CELL IMMUN, 210(2), 2001, pp. 143-153

Abstract

MHC class II-restricted antigen presentation requires trafficking of newlysynthesized class II-invariant chain complexes from the trans-Golgi network to endosomal, peptide-loading compartments. This transport is mediated bydileucine-like motifs within the cytosolic tail of the invariant chain. Although these signals have been well characterized, the cytosolic proteins that interact with these dileucine signals and mediate Golgi sorting and endosomal transport have not been identified. Recently, an adaptor complex, AP-3, has been identified that interacts with dileucine motifs and mediates endosomal/lysosomal transport in yeast, Drosophila, and mammals. In this report, we have assessed class II-invariant chain trafficking in a strain of mice (mocha) which lacks expression of AP-3. Our studies demonstrate that the lack of AP-3 does not affect the kinetics of invariant chain degradation,the route of class II-invariant chain transport, or the rate and extent ofclass II-peptide binding as assessed by the generation of SDS-stable dimers. The possible role of other known or unknown adaptor complexes in class II-invariant chain transport is discussed. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 18:49:01