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Titolo:
Immunologic approaches to the management of pancreatic cancer
Autore:
Laheru, D; Biedrzycki, B; Jaffee, EM;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Med Oncol, Baltimore, MD 21231 USA JohnsHopkins Univ Baltimore MD USA 21231 Oncol, Baltimore, MD 21231 USA
Titolo Testata:
CANCER JOURNAL
fascicolo: 4, volume: 7, anno: 2001,
pagine: 324 - 337
SICI:
1528-9117(200107/08)7:4<324:IATTMO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; CELL ANTIGEN RECEPTOR; AUTOLOGOUS MELANOMA-CELLS; LONG-TERM SURVIVAL; GROWTH-FACTOR-BETA; TUMOR-CELLS; T-CELLS; ANTITUMOR IMMUNITY; GENE-EXPRESSION; PHASE-I;
Keywords:
pancreatic cancer; immune tolerance; immunotherapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
116
Recensione:
Indirizzi per estratti:
Indirizzo: Jaffee, EM Johns Hopkins Univ, Sch Med, Dept Med Oncol, 1650 Orleans St,Bunting Blaustein Canc Res Bldg,R, Baltimore, MD 21231 USA Johns Hopkins Univ1650 Orleans St,Bunting Blaustein Canc Res Bldg,R Baltimore MD USA 21231
Citazione:
D. Laheru et al., "Immunologic approaches to the management of pancreatic cancer", CANCER J, 7(4), 2001, pp. 324-337

Abstract

Pancreatic cancer remains one of the most difficult cancers to treat; veryfew effective therapies are available, with surgery being the sole chance for cure-yet surgery is not a viable option for most pancreatic cancer patients. Immunotherapy has the potential to provide a non-cross-resistant mechanism of antitumor activity that can be integrated with surgery, radiation therapy, and chemotherapy. However, the inherent instability of the tumor genome as well as tumor tolerance mechanisms are significant practical obstacles that must be overcome if immune-based approaches for pancreatic cancercan achieve its promise. Recent advances in both tumor immunology and vaccine design have already resulted in promising preliminary data from phase Istudies, and additional trials are already in progress. This article summarizes some of the progress and challenges in immunotherapy research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:44:54