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Titolo:
The diagnosis of pancreatic cancer
Autore:
Brand, R;
Indirizzi:
Univ Nebraska, Med Ctr 982000, Sect Gastroenterol & Hepatol, Dept InternalMed, Omaha, NE 68198 USA Univ Nebraska Omaha NE USA 68198 l, Dept InternalMed, Omaha, NE 68198 USA
Titolo Testata:
CANCER JOURNAL
fascicolo: 4, volume: 7, anno: 2001,
pagine: 287 - 297
SICI:
1528-9117(200107/08)7:4<287:TDOPC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; K-RAS MUTATIONS; TELOMERASE ACTIVITY; DUCTAL ADENOCARCINOMA; TUMOR-MARKERS; ENDOSCOPIC ULTRASONOGRAPHY; IMAGING TECHNIQUES; MR CHOLANGIOPANCREATOGRAPHY; F-18 FLUORODEOXYGLUCOSE; DIFFERENTIAL-DIAGNOSIS;
Keywords:
pancreatic cancer; imaging; tumor markers; diagnosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
116
Recensione:
Indirizzi per estratti:
Indirizzo: Brand, R Univ Nebraska, Med Ctr 982000, Sect Gastroenterol & Hepatol, DeptInternalMed, Omaha, NE 68198 USA Univ Nebraska Omaha NE USA 68198 nternalMed, Omaha, NE 68198 USA
Citazione:
R. Brand, "The diagnosis of pancreatic cancer", CANCER J, 7(4), 2001, pp. 287-297

Abstract

Despite increasing interest and research on pancreatic cancer, patients with this devastating disease have a very poor prognosis. The principal reason for this grim prognosis is the inability to diagnose the disease at an early, localized, and curable stage. This review is intended to present an overview of our current status on the diagnosis of pancreatic cancer and emphasize recent advances in imaging and tumor markers that are attempting to overcome the challenges of this dreaded disease. Clinical presentation and risk factors for pancreatic cancer are reviewed. Various imaging modalities-including endoscopic and transabdominal ultrasound, ERCP, CT, MRI and PET-are described, with emphasis on their limitations for diagnosing pancreatic cancer at a size that has a significant impact on survival rates. The most promising approach for the early diagnosis of pancreatic adenocarcinoma utilizes tumor markers. Many of the tumor markers investigated over the past 20 years as well as some promising markers under current investigation are reviewed. The combination of serum markers may improve sensitivity and specificity in making the diagnosis of pancreatic adenocarcinoma. We conclude that the current status of imaging and tumor markers does not permit the early diagnosis of an adenocarcinoma of the pancreas. The development of improved early detection methods for pancreatic cancer is essential; however, at the present time it should be limited to high-risk individuals to allow fora better opportunity for success.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:47:01