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Titolo:
Familial pancreatic cancer
Autore:
Klein, AP; Hruban, RH; Brune, KA; Petersen, GM; Goggins, M;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Oncol, Baltimore, MD 21205 USA Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MDUSA Johns Hopkins Univ Baltimore MD USA th, Dept Epidemiol, Baltimore, MDUSA Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA Mayo Clin Rochester MN USA yo Clin, Dept Hlth Sci Res, Rochester, MN USA
Titolo Testata:
CANCER JOURNAL
fascicolo: 4, volume: 7, anno: 2001,
pagine: 266 - 273
SICI:
1528-9117(200107/08)7:4<266:FPC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEUTZ-JEGHERS-SYNDROME; HEREDITARY PANCREATITIS; RISK-FACTORS; CIGARETTE-SMOKING; DIABETES-MELLITUS; K-RAS; SOMATIC MUTATIONS; BRCA2 GENE; ADENOCARCINOMA; HISTORY;
Keywords:
familial pancreatic cancer; BRCA2; p16; STK11;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Goggins, M Johns Hopkins Univ, Sch Med, Dept Pathol, 632 Ross Bldg,720 Rutland St, Baltimore, MD 21205 USA Johns Hopkins Univ 632 Ross Bldg,720 Rutland St Baltimore MD USA 21205
Citazione:
A.P. Klein et al., "Familial pancreatic cancer", CANCER J, 7(4), 2001, pp. 266-273

Abstract

Pancreatic cancer is the fourth leading cause of cancer death in both men and women in the United States and will be responsible for an estimated 28,900 deaths in 2001. Relatively little is known of its etiology, and the only well-established risk factor is cigarette smoking. Studies over the past 3 decades have shown that 4%-16% of patients with pancreatic cancer have a family history of the disease. A small fraction of this aggregation can be accounted for in inherited cancer syndromes, including familial atypical multiple-mole melanoma, Peutz-Jeghers syndrome, hereditary breast-ovarian cancer, hereditary pancreatitis, and hereditary nonpolyposis colorectal cancer. These syndromes arise as a result of germline mutations in the BRCA2, p16(familial atypical multiple-mole melanoma), mismatch repair (hereditary nonpolyposis colorectal cancer), and STK11 (Peutz-Jeghers syndrome) genes. Inaddition, hereditary plays a role in predisposing certain patients with apparently sporadic pancreatic cancer. Many patients with pancreatic cancers caused by a germline mutation in a cancer-causing gene do not have a pedigree that is suggestive of a familial cancer syndrome. A recent prospective analysis of the pedigrees in the National Familial Pancreatic Tumor Registryfound that individuals with a family history of pancreatic cancer in multiple first-degree relatives have a high risk of pancreatic cancer themselves. The identification of such high-risk individuals will help clinicians target screening programs and develop preventive interventions with the hope of reducing the mortality of pancreatic cancer in these families.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:28:34