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Titolo:
Molecular pathology of pancreatic cancer
Autore:
Hruban, RH; Iacobuzio-Donahue, C; Wilentz, RE; Goggins, M; Kern, SE;
Indirizzi:
Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA Johns HopkinsMed Inst Baltimore MD USA 21205 ol, Baltimore, MD 21205 USA Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 ol, Baltimore, MD 21205 USA Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 ed, Baltimore, MD 21205 USA
Titolo Testata:
CANCER JOURNAL
fascicolo: 4, volume: 7, anno: 2001,
pagine: 251 - 258
SICI:
1528-9117(200107/08)7:4<251:MPOPC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
K-RAS MUTATIONS; TUMOR-SUPPRESSOR GENE; ENDOBILIARY BRUSH CYTOLOGY; P53 PROTEIN; INTRAEPITHELIAL NEOPLASIA; DUCTAL ADENOCARCINOMA; SOMATIC MUTATIONS; DPC4 INACTIVATION; CELL TUMORS; HEAD REGION;
Keywords:
pancreatic cancer; tumor suppressor gene; oncogene; p16; p53; K-ras; DPC4;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
112
Recensione:
Indirizzi per estratti:
Indirizzo: Hruban, RH Johns Hopkins Univ Hosp, Weinberg 2242,401 N Broadway, Baltimore, MD 21231USA Johns Hopkins Univ Hosp Weinberg 2242,401 N Broadway Baltimore MD USA 21231
Citazione:
R.H. Hruban et al., "Molecular pathology of pancreatic cancer", CANCER J, 7(4), 2001, pp. 251-258

Abstract

Until recently, pancreatic cancer was a poorly understood disease. Research in the past decade has shown conclusively, however, that pancreatic cancer is primarily genetic in nature. Inactivation with a variety of tumor-suppressor genes such as p16, DPC4, and p53, coupled with activation of oncogenes such as K-ras, are a few of the mutations that trigger the growth of cancerous cells. Understanding these mutations is critical to a better understanding of familial pancreatic cancer and to the development of gene-based screening tests and therapies. In this article, we review the genetic alterations identified in pancreatic cancer and provide examples of how this information can be applied to patient care.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 05:01:45