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Titolo:
TP53 polymorphism, HPV infection, and risk of cervical cancer
Autore:
Klug, SJ; Wilmotte, R; Santos, C; Almonte, M; Herrero, R; Guerrero, I; Caceres, E; Peixoto-Guimaraes, D; Lenoir, G; Hainaut, P; Walboomers, JMM; Munoz, N;
Indirizzi:
Univ Bielefeld, Sch Publ Hlth, AG3 Epidemiol & Med Stat, D-33501 Bielefeld, Germany Univ Bielefeld Bielefeld Germany D-33501 tat, D-33501 Bielefeld, Germany Int Agcy Res Canc, F-69372 Lyon, France Int Agcy Res Canc Lyon France F-69372 gcy Res Canc, F-69372 Lyon, France Ctr Invest Canc Maes Heller, Lima, Peru Ctr Invest Canc Maes Heller LimaPeru vest Canc Maes Heller, Lima, Peru Free Univ Amsterdam Hosp, Amsterdam, Netherlands Free Univ Amsterdam HospAmsterdam Netherlands , Amsterdam, Netherlands
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 9, volume: 10, anno: 2001,
pagine: 1009 - 1012
SICI:
1055-9965(200109)10:9<1009:TPHIAR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
P53 CODON-72 POLYMORPHISM; HUMAN-PAPILLOMAVIRUS TYPE-16; WILD-TYPE P53; CARCINOGENESIS; GENOTYPES; VARIANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Klug, SJ Univ Bielefeld, Sch Publ Hlth, AG3 Epidemiol & Med Stat, POB 100131, D-33501 Bielefeld, Germany Univ Bielefeld POB 100131 Bielefeld GermanyD-33501 eld, Germany
Citazione:
S.J. Klug et al., "TP53 polymorphism, HPV infection, and risk of cervical cancer", CANC EPID B, 10(9), 2001, pp. 1009-1012

Abstract

The role of a polymorphism at position 72 of the tumor suppressor gene TP53 in the development of cervical cancer is not well established. The arginine variant of the p53 protein could be more susceptible to degradation by human papillomavirus (HPV) E6 protein than the protein containing proline. Recent studies show controversial results. We investigated a possible association between TP53 polymorphism and cervical cancer in a Peruvian population with high prevalence of HPV infection. HPV status and TP53 polymorphism were determined for 119 cases of invasive cervical cancer and 127 control women from Peru. HPV infection was detected by PCR of cervical cells or tumorbiopsies. For determination of TP53 polymorphism, exon 4 of the TP53 gene was amplified by PCR, and DNA was subsequently subjected to restriction enzyme digest. Associations between TP53 polymorphism, HPV infection, and cervical cancer were assessed using logistic regression. Women homozygotes for arginine had a 2.2-fold increased risk (95% confidence interval: 0.6-7.6) for cervical cancer. The odds ratio for women heterozygotes for Arg/Pro was 3.5 (95% confidence interval: 0.9-14). Similarly increased risks were foundwhen restricting analysis to HPV-positive women only. The distribution of TP53 genotypes in this Peruvian population was comparable with that found in Caucasians. Our results cannot rule out an association between the TP53 polymorphism. at codon 72, HPV infection, and the etiology of cervical cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:10:56