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Titolo:
Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level
Autore:
Samowitz, WS; Curtin, K; Ma, KN; Schaffer, D; Coleman, LW; Leppert, M; Slattery, ML;
Indirizzi:
Univ Utah, Hlth Sci Ctr, Dept Pathol, Salt Lake City, UT 84132 USA Univ Utah Salt Lake City UT USA 84132 athol, Salt Lake City, UT 84132 USA Univ Utah, Hlth Sci Ctr, Dept Human Genet, Salt Lake City, UT 84132 USA Univ Utah Salt Lake City UT USA 84132 Genet, Salt Lake City, UT 84132 USA Hlth Res Ctr, Dept Family & Prevent Med, Salt Lake City, UT 84108 USA HlthRes Ctr Salt Lake City UT USA 84108 ed, Salt Lake City, UT 84108 USA Kaiser Permanente Med Care Program, Div Res, Oakland, CA 94611 USA Kaiser Permanente Med Care Program Oakland CA USA 94611 and, CA 94611 USA
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 9, volume: 10, anno: 2001,
pagine: 917 - 923
SICI:
1055-9965(200109)10:9<917:MIISCC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPLICATION ERROR PHENOTYPE; HEREDITARY COLORECTAL-CANCER; CLINICOPATHOLOGICAL VARIABLES; MISMATCH REPAIR; HMLH1 PROMOTER; GENOMIC INSTABILITY; YOUNG-PATIENTS; CELL-LINES; CARCINOMA; INDICATOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Samowitz, WS Univ Utah, Hlth Sci Ctr, Dept Pathol, Salt Lake City, UT 84132 USA Univ Utah Salt Lake City UT USA 84132 ake City, UT 84132 USA
Citazione:
W.S. Samowitz et al., "Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level", CANC EPID B, 10(9), 2001, pp. 917-923

Abstract

Some previous studies have reported an improved prognosis in sporadic colon cancers with microsatellite instability, whereas others have not. In addition, relatively few of those reporting an improved prognosis controlled for tumor stage or were population-based. Therefore, we evaluated the relationship between microsatellite instability and prognosis, tumor stage, and other clinical variables in a population-based study of 1026 individuals. Microsatellite instability was determined by the noncoding mononucleotide repeat BAT-26 and the coding mononucleotide repeat in transforming growth factor-beta receptor type II. Significant relationships were seen between microsatellite instability and proximal tumor location, female gender, young and old age at diagnosis, poor histological differentiation, and low tumor stage (P < 0.01). There was a significant relationship between microsatellite instability and improved prognosis, even after adjusting for stage, with a reduction in the risk of death attributable to colon cancer of <similar to>60%. Most of this risk reduction occurred in individuals with American JointCommittee on Cancer stage III tumors, although transforming growth factor-beta receptor type II mutations were associated with a significant reduction in colon cancer death in tumors with distant metastases. We conclude thatmicrosatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level.

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Documento generato il 21/01/21 alle ore 04:14:24