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Titolo:
Fetal bone metabolism in normal and rhesus isoimmunised pregnancies
Autore:
Ogueh, O; Wright, EM; Jones, J; Alaghband-Zadeh, J; Nicolaides, KH; Johnson, MR;
Indirizzi:
Chelsea & Westminster Hosp, Dept Maternal & Fetal Med, Imperial Coll, Sch Med, London, England Chelsea & Westminster Hosp London England oll, Sch Med, London, England Hammersmith Hosp, Dept Med Stat & Evaluat, Imperial Coll, Sch Med, London,England Hammersmith Hosp London England Imperial Coll, Sch Med, London,England Charing Cross Hosp, Dept Chem Pathol, Imperial Coll, Sch Med, London, England Charing Cross Hosp London England perial Coll, Sch Med, London, England Univ London Kings Coll Hosp, Harris Birthright Res Ctr Fetal Med, London, England Univ London Kings Coll Hosp London England r Fetal Med, London, England
Titolo Testata:
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
fascicolo: 9, volume: 108, anno: 2001,
pagine: 986 - 992
SICI:
1470-0328(200109)108:9<986:FBMINA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
I COLLAGEN-SYNTHESIS; TERMINAL PROPEPTIDE; SERUM MARKERS; HUMAN FETUS; GESTATIONAL-AGE; DEGRADATION; PROCOLLAGEN; GROWTH; RADIOIMMUNOASSAY; TELOPEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ogueh, O McGill Univ, Royal Victoria Hosp, Dept Obstet & Gynecol, Suite F4-46,687 Pine Ave W, Montreal, PQ H3A 1A1, Canada McGill Univ Suite F4-46,687 Pine Ave W Montreal PQ Canada H3A 1A1
Citazione:
O. Ogueh et al., "Fetal bone metabolism in normal and rhesus isoimmunised pregnancies", BR J OBST G, 108(9), 2001, pp. 986-992

Abstract

Objective To construct gestation-specific reference intervals for fetal concentrations of biochemical markers of bone metabolism and assess the effect of rhesus isoimmunisation on these. Methods Fetal blood samples were obtained by cordocentesis from 175 pregnancies (43 complicated by rhesus isoimmunisation) and assayed for carboxy terminal pro-peptide of type I pro-collagen (PICP) and cross-linked carboxyterminal telopeptide of type I collagen (ICTP) which directly monitor the rate of bone formation and resorption respectively. Results Both plasma PICP and ICTP were negatively correlated with gestational age (r = -0.351 and -0.472 for PICP and ICTP, respectively, and P < 0.001 for both). In fetuses affected by rhesus isoimmunisation PICP levels were lower (P = 0.030) and more variable (P < 0.001) than expected, compared with normal unaffected fetuses. However, no such differences were found in the ICTP levels. In the fetuses affected by rhesus isoimmunisation there wasa significant correlation between haemoglobin concentration and both PICP (r = 0.504, P = 0.001) and ICTP (r = 0.343, P = 0.030). Conclusions Fetal bone turnover declines from early second trimester to term, and may be deranged in fetuses affected by rhesus isoimmunisation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:06:10