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Titolo:
Expression of death-related proteins in dentate granule cells in human bacterial meningitis
Autore:
Gerber, J; Bruck, W; Stadelmann, C; Bunkowski, S; Lassmann, H; Nau, R;
Indirizzi:
Univ Gottingen, Dept Neurol, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 rol, D-37075 Gottingen, Germany Humboldt Univ, Dept Neuropathol, Charite, Berlin, Germany Humboldt Univ Berlin Germany Dept Neuropathol, Charite, Berlin, Germany Univ Vienna, Inst Brain Res, Dept Neuroimmunol, Vienna, Austria Univ Vienna Vienna Austria rain Res, Dept Neuroimmunol, Vienna, Austria
Titolo Testata:
BRAIN PATHOLOGY
fascicolo: 4, volume: 11, anno: 2001,
pagine: 422 - 431
SICI:
1015-6305(200110)11:4<422:EODPID>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BCL-X EXPRESSION; WILD-TYPE P53; CEREBRAL-ISCHEMIA; IN-VIVO; APOPTOSIS; BAX; GENE; HIPPOCAMPUS; NECROSIS; GYRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Nau, R Univ Gottingen, Dept Neurol, Robert Koch Str 40, D-37075 Gottingen,Germany Univ Gottingen Robert Koch Str 40 Gottingen Germany D-37075 ermany
Citazione:
J. Gerber et al., "Expression of death-related proteins in dentate granule cells in human bacterial meningitis", BRAIN PATH, 11(4), 2001, pp. 422-431

Abstract

Neuronal apoptosis in the dentate gyrus has been observed in animal modelsof bacterial meningitis and in humans dying in the course of the disease. To evaluate the mechanisms of neuronal cell death, hippocampal sections of 20 patients dying from bacterial meningitis were investigated by immunohistochemistry using antibodies against the proform of caspase-3 and the activeenzyme, bcl-2, bax and p53. In the dentate granule cell layer, the median density of neurons with an apoptotic morphology was 7.6/mm(2) (0-15.6/mm(2)). The median density of immunoreactive neurons was 2.3/mm(2) (procaspase-3), 0.9/mm(2) (activated caspase-3), 1.8/mm(2) (bcl-2), 1.1/mm(2) (bax) and 0.4/mm(2) (p53). 80% of neurons immunoreactive for active caspase-3 had an apoptotic morphology, whereas only 10% of all procaspase-3 stained neurons showed signs of apoptosis. Apoptotic cell death is present in humans dying in the course of bacterial meningitis in the dentate gyrus of the Formatio hippocampi. Neuronal expression of caspase-3, bcl-2 and bax suggests an involvement of these proteins in neuronal death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:57:27