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Titolo:
Superior survival of blood and marrow stem cell recipients given maternal grafts over recipients given paternal grafts
Autore:
Tamaki, S; Ichinohe, T; Matsuo, K; Hamajima, N; Hirabayashi, N; Dohy, H;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Hematol Oncol, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Dept Hematol Oncol, Kyoto 6068507, Japan Yamada Red Cross Hosp, Dept Internal Med, Misono, Japan Yamada Red Cross Hosp Misono Japan sp, Dept Internal Med, Misono, Japan Aichi Canc Ctr, Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi 464, Japan Aichi Canc Ctr Nagoya Aichi Japan 464 & Prevent, Nagoya, Aichi 464, Japan Japan Soc Hematopoiet Cell Transplanatat, Off Nationwide Survey, Nagoya, Aichi, Japan Japan Soc Hematopoiet Cell Transplanatat Nagoya Aichi Japan Aichi, Japan Nagoya Daini Red Cross Hosp, Dept Hematol, Nagoya, Aichi, Japan Nagoya Daini Red Cross Hosp Nagoya Aichi Japan tol, Nagoya, Aichi, Japan Hiroshima Red Cross Hosp, Dept Internal Med, Hiroshima, Japan Hiroshima Red Cross Hosp Hiroshima Japan Internal Med, Hiroshima, Japan Atom Bomb Survirors Hosp, Hiroshima, Japan Atom Bomb Survirors Hosp Hiroshima Japan rvirors Hosp, Hiroshima, Japan
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 4, volume: 28, anno: 2001,
pagine: 375 - 380
SICI:
0268-3369(200108)28:4<375:SSOBAM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
UMBILICAL-CORD BLOOD; PERIPHERAL-BLOOD; HLA ANTIGENS; TRANSPLANTATION; MICROCHIMERISM; LEUKEMIA; DONORS; MOTHER; POSTPARTUM; LONG;
Keywords:
alternative familial donor; HLA-incompatible transplantation; feto-maternal microchimerism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Ichinohe, T Kyoto Univ, Grad Sch Med, Dept Hematol Oncol, 54 Shogoin Kawaharacho, Kyoto 6068507, Japan Kyoto Univ 54 Shogoin Kawaharacho Kyoto Japan6068507 , Japan
Citazione:
S. Tamaki et al., "Superior survival of blood and marrow stem cell recipients given maternal grafts over recipients given paternal grafts", BONE MAR TR, 28(4), 2001, pp. 375-380

Abstract

During the reproductive period, mothers and offspring exchange hematopoietic cells and develop a form of immunological tolerance bidirectionally. To examine whether previous experience of such communication has any remote effect when maternal hematopoietic cells are later transplanted to the children, we retrospectively compared the outcomes of blood and marrow stem cell transplantation from maternal donors (n = 46) to those from paternal donors(n = 50) by using the database of the Japanese nationwide surveys for adult hematopoietic cell transplants between 1990 and 1998. At 5 years, recipients of maternal hematopoietic cells had a significantly higher overall survival than patients receiving paternal grafts (60% vs 32%, P = 0.006). Although no significant difference was observed in the occurrence of severe acute GVHD (grade greater than or equal to III) and the relapse of malignant diseases between two groups, the probability of non-relapse treatment-relatedmortality was significantly lower after maternal donor transplants. Furthermore, multivariate analysis revealed that parental donor type was the onlyfactor significantly associated with overall survival. In conclusion, our analysis indicates superior survival of maternally donated recipients in hematopoietic stem-cell transplantations from biological parents. This finding has important implications in the selection of alternative familial donors, and warrants further prospective analysis of parental donor transplantations.

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Documento generato il 29/03/20 alle ore 15:05:04