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Titolo:
Synergistic effects of pegylated recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor on mobilization of hematopoietic progenitor and stem cells with long-term repopulating ability into peripheral blood in mice
Autore:
Honda, K; Takenaka, K; Shinagawa, K; Ishimaru, F; Ikeda, K; Niiya, K; Harada, M;
Indirizzi:
Okayama Univ, Sch Med, Dept Internal Med 2, Okayama 7008558, Japan OkayamaUniv Okayama Japan 7008558 nternal Med 2, Okayama 7008558, Japan
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 4, volume: 28, anno: 2001,
pagine: 329 - 334
SICI:
0268-3369(200108)28:4<329:SEOPRH>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-MPL LIGAND; HUMAN THROMBOPOIETIN; IN-VIVO; ACCELERATES PLATELET; NONHUMAN-PRIMATES; ADVANCED CANCER; FLT-3 LIGAND; PEG-RHUMGDF; PROLIFERATION; CHEMOTHERAPY;
Keywords:
thrombopoietin; megakaryocyte growth and development factor; granulocyte colony; stimulating factor; mobilization; peripheral blood progenitor cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Honda, K Okayama Univ, Sch Med, Dept Internal Med 2, 2-5-1 Shikatacho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikatacho Okayama Japan 7008558 08558, Japan
Citazione:
K. Honda et al., "Synergistic effects of pegylated recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor on mobilization of hematopoietic progenitor and stem cells with long-term repopulating ability into peripheral blood in mice", BONE MAR TR, 28(4), 2001, pp. 329-334

Abstract

We investigated the effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on peripheral blood progenitor cell (PBPC) mobilization and the combined effect of PEG-rHuMGDF plus recombinant human granulocyte colony-stimulating factor (rhG-CSF) in C57BL/6 mice. Treatment of mice with PEG-rHuMGDF increased the numbers of day 8 and day 12 spleen colony-forming units (CFU-S), and pre-CFU-S in the PB. Ten days administration of PEG-rHuMGDF could mobilize higher numbers of days 8 and day 12 CFU-S than 5 days administration. An optimal dose of PEG-rHuMGDF mobilized a higher number of committed progenitor cells (day 8 CFU-S) and a lower number of immature progenitor cells (pre-CFU-S) into PB than rhG-CSF. Thecombined administration of optimal or suboptimal doses of PEG-rHuMGDF and rhG-CSF induced synergistic effects on mobilization of CFU-S and pre-CFU-S into PB compared to either factor alone. Four months after sex-mismatched PBPC transplantation, long-term donor-derived engraftment was observed in all recipients that had been transplanted with PBPCs mobilized by rhG-CSF and/or PEG-rHuMGDF, as determined by Y-chromosome polymerase chain reaction (PCR) analysis. Our data suggest that cytokine-induced pathways for PBPC mobilization may be different between PEG-rHuMGDF and rhG-CSF and indicate thatPEG-rHuMGDF alone or the combination with rhG-CSF may be useful in effective PBPC mobilization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 01:02:55