Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparative effects of dietary fat types on hepatic enzyme activities related to the synthesis and oxidation of fatty acid and to lipogenesis in rats
Autore:
Takeuchi, H; Nakamoto, T; Mori, Y; Kawakami, M; Mabuchi, H; Ohishi, Y; Ichikawa, N; Koike, A; Masuda, K;
Indirizzi:
Univ Shizuoka, Fac Agr, Dept Appl Biol Chem, Shizuoka 4228529, Japan Univ Shizuoka Shizuoka Japan 4228529 Biol Chem, Shizuoka 4228529, Japan
Titolo Testata:
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
fascicolo: 8, volume: 65, anno: 2001,
pagine: 1748 - 1754
SICI:
0916-8451(200108)65:8<1748:CEODFT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIACYLGLYCEROL ACYLTRANSFERASE; BETA-OXIDATION; FISH OIL; LIVER; TRIACYLGLYCEROL; CHOLESTEROL; PLASMA; OMEGA-3; N-3; METABOLISM;
Keywords:
dietary fat; enzymes for fatty acid synthesis; enzymes for lipogenesis; enzymes for beta-oxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Takeuchi, H 2787-34 Ohya, Shizuoka 4228017, Japan 2787-34 Ohya Shizuoka Japan 4228017 Shizuoka 4228017, Japan
Citazione:
H. Takeuchi et al., "Comparative effects of dietary fat types on hepatic enzyme activities related to the synthesis and oxidation of fatty acid and to lipogenesis in rats", BIOS BIOT B, 65(8), 2001, pp. 1748-1754

Abstract

The effects of different types of dietary fat on the activities of hepaticenzymes related to fatty acid synthesis (glucose-6-phosphate dehydrogenase(G6PDH) and acetyl-CoA carboxylase (ACC)), oxidation (acyl-CoA synthetase (AST), carnitine palmitoyl transferase (CPT), and peroxisomal beta -oxidation (P beta OX)), and lipogenesis (phosphatidate phosphohydrolase (PAP), diacylglycerol acyltransferase (DGAT), and phosphocholine diacylglycerol transferase (PCDGT)), and plasma and liver lipid levels were investigated in male Wistar rats. The animals were 6 weeks old and about 120 g of body weight,and were fed on test diets containing 20% of a mixture of tripalmitin, tristearin and corn oil (SFA), olive oil (OLI), sunflower oil (SUN), linseed oil (LIS), and sardine oil (SAR) for 2 weeks. The concentrations of plasma total cholesterol (T-CHOL), high-density lipoprotein-cholesterol (HDL-CHOL),triacylglycerol (TG) and phospholipid (PL) were generally higher in the rats fed on SFA and OLI than in those given SUN, LIS and SAR. The rats fed onOLI had a higher level of liver T-CHOL than those fed on the other fats. The liver TG content was nearly higher from the intake of SFA and OLI than from SUN, LIS and SAR, although the liver PL level was not affected by the type of dietary fat. The SFA and OLI groups had the highest activities of hepatic G6PDH and ACC, and the SAR group, the lowest activities. The activities of AST and CPT, and peroxisomal P beta OX in the liver were higher in the rats fed on the LIS and SAR diets than in those given the other diets. The hepatic PAP activity was higher from the intake of OLI and SUN, and tended to be higher from SFA than from LIS and SAR. The activity of liver DGAT was higher from SFA and inclined to be higher from OLI, SUN, and LIS than from SAR, while the PCDGT activity in the liver was not effected by the type of dietary fat. The concentrations of plasma and liver TG were generally positively correlated with the activities of liver enzymes related to the synthesis of fatty acids and lipids, and negatively with those involved in fatty acid oxidation. Based on these results, it is suggested that the levels of plasma and liver TG were controlled by different types of dietary fat through changes in the hepatic enzyme activities related to fatty acid synthesis, lipogenesis, and fatty acid oxidation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:10:45