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Titolo:
Total synthesis of Calebin-A, preparation of its analogues, and their neuronal cell protectivity against beta-amyloid insult
Autore:
Kim, DSHL; Kim, JY;
Indirizzi:
Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago,IL 60612 USA Univ Illinois Chicago IL USA 60612 s Pharmaceut Sci, Chicago,IL 60612 USA Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 & Pharmacognosy, Chicago, IL 60612 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 18, volume: 11, anno: 2001,
pagine: 2541 - 2543
SICI:
0960-894X(20010917)11:18<2541:TSOCPO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLIFERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, DSHL Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, 833 S Wood St, Chicago, IL 60612 USA Univ Illinois 833 S Wood St Chicago IL USA 60612 o, IL 60612 USA
Citazione:
D.S.H.L. Kim e J.Y. Kim, "Total synthesis of Calebin-A, preparation of its analogues, and their neuronal cell protectivity against beta-amyloid insult", BIOORG MED, 11(18), 2001, pp. 2541-2543

Abstract

A total synthesis of Calebin-A (1), a novel curcuminoid isolated from turmeric (Curcuma longa, Zingiberaceae) that has been demonstrated to protect neuronal cells from beta -amyloid insult, was successfully achieved in four steps. Elaborating on this synthetic route. 13 analogues were prepared for a structure-activity relationship (SAR) study. It was found that the parentcompound 1 and derivatives 21, 28, and 30 protect PC12 rat pheocromocytomaand IMR-32 human neuroblastoma cells from beta -amyloid(25-35) insult. These results suggest that hydroxy group at para-position is most critical forthe expression of biological activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 14:57:55