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Titolo:
Brain gangliosides: Functional ligands for myelin stability and the control of nerve regeneration
Autore:
Vyas, AA; Schnaar, RL;
Indirizzi:
Johns Hopkins Sch Med, Dept Pharmacol, Baltimore, MD 21205 USA Johns Hopkins Sch Med Baltimore MD USA 21205 col, Baltimore, MD 21205 USA Johns Hopkins Sch Med, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Sch Med Baltimore MD USA 21205 sci, Baltimore, MD 21205 USA
Titolo Testata:
BIOCHIMIE
fascicolo: 7, volume: 83, anno: 2001,
pagine: 677 - 682
SICI:
0300-9084(200107)83:7<677:BGFLFM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID-BINDING-RECEPTOR; IMMUNOGLOBULIN SUPERFAMILY; COMPLEX GANGLIOSIDES; AXONAL REGENERATION; SIALOADHESIN FAMILY; NEURITE OUTGROWTH; KNOCKOUT MICE; GLYCOPROTEIN; INHIBITOR; MOLECULES;
Keywords:
gangliosides; myelin-associated glycoprotein; axon regeneration; lectin; Siglec;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Schnaar, RL Johns Hopkins Sch Med, Dept Pharmacol, 318 WBSB,725 N Wolfe St, Baltimore,MD 21205 USA Johns Hopkins Sch Med 318 WBSB,725 N Wolfe St Baltimore MD USA 21205
Citazione:
A.A. Vyas e R.L. Schnaar, "Brain gangliosides: Functional ligands for myelin stability and the control of nerve regeneration", BIOCHIMIE, 83(7), 2001, pp. 677-682

Abstract

Gangliosides, sialylated glycosphingolipids which are the predominant glycans on vertebrate nerve cell surfaces, are emerging as components of membrane rafts, where they can mediate important physiological functions. Myelin associated glycoprotein (MAG), a minor constituent of myelin, is a sialic acid binding lectin with two established physiological functions: it is involved in myelin-axon stability and cytoarchitecture, and controls nerve regeneration. MAG is found selectively on the myelin membranes directly apposedto the axon surface, where it has been proposed to mediate myelin-axon interactions. Although the nerve cell surface ligands for MAG remain to be established, evidence supports a functional role for sialylated glycoconjugates. Here we review recent studies that reflect on the role of gangliosides, sialylated glycosphingolipids, as functional MAG ligands. MAG binds to gangliosides with the terminal sequence 'NeuAc alpha 3Gal beta 3GalNAc' which is found on the major nerve gangliosides GD1a and GT1b. Gangliosides lackingthat terminus (e.g., GM1 or GD1b), or having any biochemical modification of the terminal NeuAc residue fail to support MAG binding. Genetically engineered mice lacking the GalNAc transferase required for biosynthesis of the'NeuAca3Gal beta 3GalNAc' terminus have grossly impaired myelination and progressive neurodegeneration. Notably the MAG level in these animals is dysregulated. Furthermore, removal of NeuAc residues from nerve cells reversesMAG-mediated inhibition of neuritogenesis, and neurons from mice lacking the 'NeuAca3Gal beta 3GalNAc' terminus have an attenuated response to MAG. Cross-linking nerve cell surface gangliosides can mimic MAG-mediated inhibition of nerve regeneration. Taken together these observations implicate gangliosides as functional MAG ligands. (C) 2001 Societe francaise de biochimieet biologie moleculaire Editions scientifiques et medicales Elsevier SAS. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:59:28