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Titolo:
The alpha-gal epitope (Gal alpha 1-3Gal beta 1-4GlcNAc-R) in xenotransplantation
Autore:
Galili, U;
Indirizzi:
Rush Univ, Dept Cardiovasc Thorac Surg, Chicago, IL 60612 USA Rush Univ Chicago IL USA 60612 diovasc Thorac Surg, Chicago, IL 60612 USA
Titolo Testata:
BIOCHIMIE
fascicolo: 7, volume: 83, anno: 2001,
pagine: 557 - 563
SICI:
0300-9084(200107)83:7<557:TAE(A1>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR SWINE XENOANTIGEN; ASPARAGINE-LINKED OLIGOSACCHARIDES; BOVINE CARTILAGE TRANSPLANTS; AORTIC ENDOTHELIAL-CELLS; ASCITES TUMOR-CELLS; BLOOD-GROUP-B; GALACTOSYL EPITOPE; CYNOMOLGUS MONKEY; MEDIATED ACTIVATION; DIABETIC-PATIENTS;
Keywords:
xenotransplantation; alpha-Gal epitope; pig xenografts;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Galili, U Rush Univ, Dept Cardiovasc Thorac Surg, 1653 W Congress Pkwy, Chicago, IL 60612 USA Rush Univ 1653 W Congress Pkwy Chicago IL USA 60612 IL 60612 USA
Citazione:
U. Galili, "The alpha-gal epitope (Gal alpha 1-3Gal beta 1-4GlcNAc-R) in xenotransplantation", BIOCHIMIE, 83(7), 2001, pp. 557-563

Abstract

Many patients with failing organs (e.g., heart, liver or kidneys), do not receive the needed organ because of an insufficient number of organ donors. Pig xenografts have been considered as an alternative source of organs fortransplantation. The major obstacle currently known to prevent pig to human xenotransplantation is the interaction between the human natural anti-Galantibody and the alpha -gal epitope (Gal alpha1-3Gal beta1-4GlcNAc-R), abundantly expressed on pig cells. This short review describes the characteristics of anti-Gal and of the alpha -gal epitope, their role in inducing xenograft rejection and some experimental approaches for preventing this rejection. (C) 2001 Societe francaise de biochimie et biologie moleculaire / Editions scientifiques et medicales Elsevier SAS. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 02:12:23