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Titolo:
The mechanism of protein kinase regulation by protein phosphatases
Autore:
Barford, D;
Indirizzi:
Inst Canc Res, Chester Beatty Labs, Sect Struct Biol, London SW3 6JB, England Inst Canc Res London England SW3 6JB truct Biol, London SW3 6JB, England
Titolo Testata:
BIOCHEMICAL SOCIETY TRANSACTIONS
, volume: 29, anno: 2001,
parte:, 4
pagine: 385 - 391
SICI:
0300-5127(200108)29:<385:TMOPKR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIN-DEPENDENT KINASES; CRYSTAL-STRUCTURE; INSULIN-RECEPTOR; ACTIVATION; CDK2; KAP; 1B;
Keywords:
dual specificity protein phosphatases (DSPs); insulin receptor; insulin receptor kinase (IRK); kinase-associated phosphatase (KAP); phosphoproteins; protein tyrosine phosphatase IB; (PTP IB);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Barford, D Inst Canc Res, Chester Beatty Labs, Sect Struct Biol, 237 Fulham Rd, London SW3 6JB, England Inst Canc Res 237 Fulham Rd London England SW3 6JB JB, England
Citazione:
D. Barford, "The mechanism of protein kinase regulation by protein phosphatases", BIOCH SOC T, 29, 2001, pp. 385-391

Abstract

Protein kinases are an important class of substrate of the protein phosphatases. We have examined the mechanism of dephosphorylation of the activation segments of the insulin receptor kinase and cyclin-dependent kinase 2 by their respective phosphatases, namely the tyrosine specific phosphatase PTP1B and the dual specificity phosphatase KAP. These studies reveal that PTP1B and KAP utilize contrasting mechanisms in order to dephosphorylate their substrates specifically.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:07:43