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Titolo:
MORPHOLOGICAL CHANGE IN TUMOR ENDOTHELIAL-CELLS INDUCED BY NATURAL-TYPE HUMAN TUMOR-NECROSIS-FACTOR
Autore:
NAKAICHI M; TAKEUCHI A; SASAKI N; SHITARA N; TAKAKURA K;
Indirizzi:
YAMAGUCHI UNIV,DEPT VET SURG YAMAGUCHI 753 JAPAN IWATE UNIV,VET HOSP MORIOKA IWATE 020 JAPAN UNIV TOKYO,DEPT VET SURG,BUNKYO KU TOKYO 113 JAPAN TOKYO METROPOLITAN KOMAGOME HOSP,BUNKYO KU TOKYO 113 JAPAN TOKYO WOMENS MED COLL,SHINJUKU KU TOKYO 162 JAPAN
Titolo Testata:
Journal of veterinary medical science
fascicolo: 7, volume: 59, anno: 1997,
pagine: 605 - 608
SICI:
0916-7250(1997)59:7<605:MCITEI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTIC INFILTRATION; ACTIVATION; SKIN;
Keywords:
HIGH ENDOTHELIAL VENULE; TUMOR ENDOTHELIAL CELL; TUMOR NECROSIS FACTOR (TNF);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
M. Nakaichi et al., "MORPHOLOGICAL CHANGE IN TUMOR ENDOTHELIAL-CELLS INDUCED BY NATURAL-TYPE HUMAN TUMOR-NECROSIS-FACTOR", Journal of veterinary medical science, 59(7), 1997, pp. 605-608

Abstract

The effects of natural-type human tumor necrosis factor (nh-TNF) on tumor endothelial cells of experimental brain tumors were investigated electron microscopically. Tumor vessels with hypertrophic endothelial cells were observed 12 and 24 hr after an intralesional administrationof 5,000 U of nh-TNF. Increased biosynthetic organelles such as the Golgi complex and rough endoplasmic reticulum were evident in the plumpcytoplasms. These endothelial cells resembled those in high endothelial venules (HEV) functionally characterized by the high permeability of leukocytes. In addition, close interactions between these endothelial cells and leukocytes were observed. Our findings indicated that nh-TNF could promote the morphological change in tumor endothelial cells into HEV-like cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:55:30