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Titolo:
Is the use of albumin in colloid prime solution of cardiopulmonary bypass circuit justified?
Autore:
Boks, RH; van Herwerden, LA; Takkenberg, JJM; van Oeveren, W; Gu, YJ; Wijers, MJ; Bogers, AJJC;
Indirizzi:
Erasmus Univ, Med Ctr, Dept Cardiothorac Surg, Div Extracorporeal Circulat, NL-3015 GD Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3015 GD GD Rotterdam, Netherlands Univ Groningen Hosp, Dept Cardiothorac Surg, Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands Surg, Groningen, Netherlands
Titolo Testata:
ANNALS OF THORACIC SURGERY
fascicolo: 3, volume: 72, anno: 2001,
pagine: 850 - 853
SICI:
0003-4975(200109)72:3<850:ITUOAI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANAPHYLACTOID REACTIONS; PLASMA SUBSTITUTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Boks, RH Erasmus Univ, Med Ctr, Dept Cardiothorac Surg, Div ExtracorporealCirculat, Bd 467,Dr Molewaterpl 40, NL-3015 GD Rotterdam, Netherlands Erasmus Univ Bd 467,Dr Molewaterpl 40 Rotterdam Netherlands NL-3015 GD
Citazione:
R.H. Boks et al., "Is the use of albumin in colloid prime solution of cardiopulmonary bypass circuit justified?", ANN THORAC, 72(3), 2001, pp. 850-853

Abstract

Background. Albumin in the priming solution precoats the surface of the cardiopulmonary bypass circuit, supposedly causing delayed adsorption of fibrinogen and reduced activation and adhesion of platelets. This action may result in lower transoxygenator resistance. Because our institution uses a colloidal prime solution (Gelo-fusine), questions were raised about the valueof albumin in the prime solution. We decided to focus on the clinical effects of transoxygenator resistance. Methods. Sixty adults undergoing elective cardiac operations were randomlydivided into three groups: a group with 20-g albumin (n = 20), a group with 2-g albumin (n = 20), and a group with no albumin (n = 20) in the 1,600-mL colloidal prime. Patients older than 75 years and patients with a preoperative serum albumin level of 30 g/L or less were excluded. The transoxygenator resistance was measured throughout cardiopulmonary bypass. beta -Thromboglobulin levels were used to study contact activation of platelets. Measures of prothrombin F1,2 fragments were used as a marker of thrombin generation. Body surface area, age, preoperative albumin, hematocrit, hemoglobin, fibrinogen, platelet count, and colloid osmotic pressure levels were compared between groups. Results. Base line characteristics and chosen control measurements were similar for all three populations. When comparing the observed transoxygenator resistance among the three different groups, no significant differences were noted. Prothrombin F1.2 fragments remained low for all the groups without significant differences. In the no-albumin group the level of beta -thromboglobulin appeared to be higher, but the difference was not statisticallysignificant. Conclusions. Addition of albumin to prime solution in a cardiopulmonary bypass circuit that already contains colloids does not affect the transoxygenator resistance of the COBE Duo flat sheet oxygenator and does not affect prothrombin F1.2 and beta -thromboglobulin levels. Therefore additional costs for the albumin are not justified. Measurement of transoxygenator resistance is a reliable, simple method to determine the effects of a prime solution on the oxygenator surface in vivo. (C) 2001 by The Society of Thoracic Surgeons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 02:39:49