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Titolo:
Effects of NHE-1 inhibition on cardioprotection and impact on protection by K/Mg cardioplegia
Autore:
Toyoda, Y; Khan, S; Chen, WM; Parker, RA; Levitsky, S; McCully, JD;
Indirizzi:
Harvard Inst Med, Beth Israel Deaconess Med Ctr, Div Cardiothorac Surg, Boston, MA 02115 USA Harvard Inst Med Boston MA USA 02115 diothorac Surg, Boston, MA 02115 USA Beth Israel Deaconess Med Ctr, Biometr Ctr, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 r, Boston, MA 02215 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA
Titolo Testata:
ANNALS OF THORACIC SURGERY
fascicolo: 3, volume: 72, anno: 2001,
pagine: 836 - 843
SICI:
0003-4975(200109)72:3<836:EONIOC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NA+-H+ EXCHANGE; SODIUM-HYDROGEN-EXCHANGE; NUCLEAR-MAGNETIC-RESONANCE; INFARCT SIZE LIMITATION; CALCIUM ACCUMULATION; GLOBAL-ISCHEMIA; DEVELOPMENTAL DIFFERENCES; POSTISCHEMIC RECOVERY; CA2+ OVERLOAD; RABBIT HEART;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: McCully, JD Harvard Inst Med, Beth Israel Deaconess Med Ctr, Div Cardiothorac Surg, Rm144,77 Ave Louis Pasteur, Boston, MA 02115 USA Harvard Inst MedRm 144,77 Ave Louis Pasteur Boston MA USA 02115
Citazione:
Y. Toyoda et al., "Effects of NHE-1 inhibition on cardioprotection and impact on protection by K/Mg cardioplegia", ANN THORAC, 72(3), 2001, pp. 836-843

Abstract

Background. Cardiac sodium hydrogen exchanger isoform-1 (NHE-1) activity during ischemia/reperfusion contributes to myocardial injury. The effects ofNHE-1 inhibition during ischemia or reperfusion and on the protection afforded by K/Mg cardioplegia was unknown. Methods. Rabbit hearts were used for Langendorff perfusion. Control heartswere perfused for 180 minutes. Global ischemia (GI) hearts received 30 minutes normothermic global ischemia and 120 minutes reperfusion. K/Mg hearts received cardioplegia 5 minutes before ischemia. Separate groups of GI and K/Mg hearts received the NHE-1 inhibitor, HOE-642, before ischemia (HOE-642-I), at the immediate start of reperfusion (HOE-642-R), or both before ischemia and at the immediate start of reperfusion (HOE-642-IR). Results. Left ventricular peak developed pressure was significantly increased in HOE-I, HOE-R, and HOE-IR throughout reperfusion (p < 0.05 versus GI). Infarct size was significantly decreased (p < 0.05 versus GI) in all groups, but was significantly increased in HOE-R as compared with HOE-IR (p <less than> 0.05). NHE-1 inhibition with K/Mg cardioplegia significantly decreased left ventricular peak developed pressure after 90 minutes of reperfusion (p < 0.05 versus K/Mg), with no significant effect on infarct size. Conclusions. NHE-1 inhibition used alone provides cardioprotection with optimal effects being observed with HOE-IR. NHE-1 inhibition with K/Mg cardioplegia decreases postischemic functional recovery during late reperfusion. <(c)> 2001 by The Society of Thoracic Surgeons.

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Documento generato il 26/01/20 alle ore 16:22:13