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Titolo:
Discordant iodine-123 metaiodobenzylguanidine uptake area reflects recovery time dispersion in acute myocardial infarction
Autore:
Masai, M; Naruse, H; Morita, M; Arii, T; Takahashi, K; Ohyanagi, M; Iwasaki, T; Fukuchi, M;
Indirizzi:
Hyogo Med Univ, Div Cardiovasc, Dept Internal Med, Nishinomiya, Hyogo 6638501, Japan Hyogo Med Univ Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan Hyogo Med Univ, Dept Nucl Med, Nishinomiya, Hyogo 6638501, Japan Hyogo MedUniv Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan
Titolo Testata:
ANNALS OF NUCLEAR MEDICINE
fascicolo: 4, volume: 15, anno: 2001,
pagine: 357 - 363
SICI:
0914-7187(200108)15:4<357:DIMUAR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
QT INTERVAL PROLONGATION; CORONARY-ARTERY DISEASE; VENTRICULAR-TACHYCARDIA; SCINTIGRAPHIC ASSESSMENT; REPOLARIZATION; ARRHYTHMIAS; DEATH; TACHYARRHYTHMIAS; INNERVATION; MECHANISM;
Keywords:
iodine-123 metaiodobenzylguanidine; acute myocardial infarction; ventricular arrhythmia; recovery time dispersion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Masai, M Hyogo Med Univ, Div Cardiovasc, Dept Internal Med, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan Hyogo Med Univ 1-1 Mukogawa Cho Nishinomiya Hyogo Japan 6638501 n
Citazione:
M. Masai et al., "Discordant iodine-123 metaiodobenzylguanidine uptake area reflects recovery time dispersion in acute myocardial infarction", ANN NUCL M, 15(4), 2001, pp. 357-363

Abstract

Iodine-123 metaiodobenzylguanidine (MIBG) uptake was reported to be reduced compared to Tl-201 (Tl) in acute myocardial infarction (AMI). Within suchan area, degrees of both sympathetic neural function and ischemic myocardial cell damage arc considered to be greatly dispersed. These kinds of damage were reported to effect reporalization time in myocardial cells, and we evaluated our hypothesis that extension of the discordant MIBG uptake area correlates with recovery time (RT) dispersion and relate ventricular arrhythmias in AMI. MIBG and Tl images were obtained in AMI patients. Regional Tl or MIBG uptake was estimated in 9 segments of SPECT by using four-point scoring. The total score was the sum of scores in 9 SPECT segments. Delta Tl-MIBG was calculated by subtracting the total MIBG score from the total Tl score. Corrected RT (RTc) was measured as a signal-averaged ECG. RTc dispersion was defined as the difference between maximal and minimal RTc. The patients were assigned to two groups (group A; less than or equal to Lown 4a, group B; greater than or equal to Lown 4b) according to the results of 24-hour Holter monitoring. A positive correlation between RTc dispersion and Delta Tl-MIBG was found. Delta Tl-MIBG and RTc dispersion in group B were greater than those in group A. These results suggested that Delta Tl-MIBG could be used to predict the development of malignant ventricular arrhythmias.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:02:31