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Titolo:
Dissociation of brain edema induced by cold injury in rat model: MR imaging and perfusion studies with C-14-iodo-antipyrine
Autore:
Itabashi, Y; Prado, GLM; Abo, M; Miura, H; Abe, Y;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Radiol, Hirosaki, Aomori 0368652, Japan Hirosaki Univ Hirosaki Aomori Japan 0368652 rosaki, Aomori 0368652, Japan
Titolo Testata:
ANNALS OF NUCLEAR MEDICINE
fascicolo: 4, volume: 15, anno: 2001,
pagine: 337 - 342
SICI:
0914-7187(200108)15:4<337:DOBEIB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; BARRIER PERMEABILITY; DIFFUSION; CORTEX; MOUSE;
Keywords:
cold injury; MRI; autoradiography; brain perfusion; rat; edema;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Itabashi, Y Hirosaki Univ, Sch Med, Dept Radiol, 5 Zaifu Cho, Hirosaki, Aomori 0368652, Japan Hirosaki Univ 5 Zaifu Cho Hirosaki Aomori Japan 0368652 Japan
Citazione:
Y. Itabashi et al., "Dissociation of brain edema induced by cold injury in rat model: MR imaging and perfusion studies with C-14-iodo-antipyrine", ANN NUCL M, 15(4), 2001, pp. 337-342

Abstract

The purpose of this study is to confirm whether T2-weighted imaging and perfusion imaging, i.e. autoradiogram of C-14-iodoantipyrine, on the course of brain edema correspond to each other or not. Cold injured rat brains wereused as a model and were sequentially examined by both methods and compared with each other and with histological specimens. Special focus relies on the time changes in the lesions. High SI of T2-weighted images were observed and the percentages in the high SI area to the total brain area in the same slice were 4.7 +/- 0.31, 5.6 +/- 0.46 and 3.4 +/- 0.42 for 6, 24 and 48 hours, respectively. By contrast, low perfusion areas were indicated in theperfusion study and their percentages were 4.6 +/- 0.55, 5.6 +/- 0.86 and 2.4 +/- 0.35 for 6, 24 and 48 hours, respectively. At 48 hours after cold injury, low perfusion areas were smaller than high SI areas. Moreover, high accumulation areas consisting of macrophages were observed surrounding necrosis. It is concluded that there is dissociation between perfusion and T2-weighted MR imaging, where the collection of macrophages surrounding edema lesions and necrosis had the same appearance on MRI and different accumulations on perfusion studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:26:49