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Titolo:
Central and peripheral nervous system infection, immunity, and inflammation in the NHP model of Lyme borreliosis
Autore:
Pachner, AR; Cadavid, D; Shu, G; Dail, D; Pachner, S; Hodzic, E; Barthold, SW;
Indirizzi:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurosci, Newark, NJ 07103 USA Univ Med & Dent New Jersey Newark NJ USA 07103 osci, Newark, NJ 07103 USA Univ Calif Davis, Sch Med, Ctr Comparat Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Ctr Comparat Med, Davis, CA 95616 USA Univ Calif Davis, Sch Vet Med, Ctr Comparat Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Ctr Comparat Med, Davis, CA 95616 USA
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 3, volume: 50, anno: 2001,
pagine: 330 - 338
SICI:
0364-5134(200109)50:3<330:CAPNSI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHESUS-MONKEY; NEUROLOGIC MANIFESTATIONS; ANTIBODY-RESPONSE; NONHUMAN-PRIMATES; VECTOR TICKS; PROTEIN-A; DISEASE; BURGDORFERI; NEUROBORRELIOSIS; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Pachner, AR Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurosci,185 S Orange Ave, Newark, NJ 07103 USA Univ Med & Dent New Jersey 185 S Orange Ave Newark NJ USA 07103
Citazione:
A.R. Pachner et al., "Central and peripheral nervous system infection, immunity, and inflammation in the NHP model of Lyme borreliosis", ANN NEUROL, 50(3), 2001, pp. 330-338

Abstract

The relationship between chronic infection, antispirochetal immunity, and inflammation is unknown in Lyme neuroborreliosis. In the nonhuman primate model of Lyme neuroborreliosis, we measured spirochetal density in the nervous system and other tissues by polymerase chain reaction and correlated these values to anti-Borrelia burgdorferi antibody in the serum and cerebrospinal fluid, and to inflammation in tissues. Despite substantial presence of Borrelia burgdorferi, the causative agent of Lyme borreliosis, in the central nervous system, only minor inflammation was present there, though skeletal and cardiac muscle, which contained similar levels of spirochete, were highly inflamed. Anti-Borrelia burgdorferi antibody was present in the cerebrospinal fluid but was not selectively concentrated. All infected animals developed anti-Borrelia burgdorferi antibody in the serum, but increased amplitude of antibody was not predictive of higher levels of infection. These data demonstrate that Lyme neuroborreliosis is a persistent infection, thatspirochetal presence is a necessary but not sufficient condition for inflammation, and that antibody measured in serum may not predict the severity of infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 13:27:30