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Titolo:
Nigrostriatal collaterals to thalamus degenerate in parkinsonian animal models
Autore:
Freeman, A; Ciliax, B; Bakay, R; Daley, J; Miller, RD; Keating, G; Levey, A; Rye, D;
Indirizzi:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 Univ, Dept Neurol, Atlanta, GA 30322 USA Rush Presbyterian St Lukes Med Ctr, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr Chicago IL USA 60612 ago, IL 60612 USA
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 3, volume: 50, anno: 2001,
pagine: 321 - 329
SICI:
0364-5134(200109)50:3<321:NCTTDI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDBRAIN DOPAMINERGIC-NEURONS; BASAL GANGLIA; TYROSINE-HYDROXYLASE; RETICULAR NUCLEUS; SUBSTANTIA-NIGRA; MESSENGER-RNA; D-2 RECEPTOR; BRAIN; RAT; LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Rye, D Emory Univ, Dept Neurol, 1639 Pierce Dr,Suite 6000 WMRB,PO Drawer V, Atlanta, GA 30322 USA Emory Univ 1639 Pierce Dr,Suite 6000 WMRB,PO DrawerV Atlanta GA USA 30322
Citazione:
A. Freeman et al., "Nigrostriatal collaterals to thalamus degenerate in parkinsonian animal models", ANN NEUROL, 50(3), 2001, pp. 321-329

Abstract

Movement, cognition, emotion, and positive reinforcement are influenced bymesostriatal, mesocortical, and mesolimbic dopamine systems. We describe afourth major pathway originating from mesencephalic dopamine neurons: a mesothalamic system. The dopamine transporter, specific to dopamine containing axons, was histochemically visualized in thalamic motor and limbic-related nuclei and regions that modulate behavioral state as opposed to sensory nuclei in rats, nonhuman primates, and humans. Anatomical tracing established this innervation's origin via axon collaterals from the mesostriatal pathway. These findings implicate the thalamus as a novel site for disease specific alterations in dopamine neurotransmission, such as exist with nigral. degeneration attending Parkinson's disease. This was confirmed in hemiparkinsonian animals where reduction of thalamic dopamine innervation occurred coincident with signs of active axonal degeneration. Individual mesencephalic dopamine neurons therefore have the potential to modulate normal and pathologic behavior not only through traditional nigrostriatal. pathways but also by way of axon collaterals that innervate the thalamus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:25:19