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Titolo:
ANNA-3 anti-neuronal nuclear antibody: Marker of lung cancer-related autoimmunity
Autore:
Chan, KH; Vernino, S; Lennon, VA;
Indirizzi:
Mayo Clin, Dept Neurol, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 in, Dept Neurol, Rochester, MN 55905 USA Mayo Clin, Dept Immunol, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 n, Dept Immunol, Rochester, MN 55905 USA Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 ab Med & Pathol, Rochester, MN 55905 USA
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 3, volume: 50, anno: 2001,
pagine: 301 - 311
SICI:
0364-5134(200109)50:3<301:AANAMO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARANEOPLASTIC CEREBELLAR DEGENERATION; DESCRIPTIVE GENERIC NOMENCLATURE; RNA-BINDING PROTEIN; ANTIAMPHIPHYSIN ANTIBODIES; NEUROLOGICAL DISORDERS; SENSORY NEURONOPATHY; AUTOANTIBODIES; CARCINOMA; CELLS; ENCEPHALOMYELITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Lennon, VA Mayo Clin, Neuoimmunol Lab, Guggenheim Bldg,Room 838,200 First St SW, Rochester, MN 55905 USA Mayo Clin Guggenheim Bldg,Room 838,200 FirstSt SW Rochester MN USA 55905
Citazione:
K.H. Chan et al., "ANNA-3 anti-neuronal nuclear antibody: Marker of lung cancer-related autoimmunity", ANN NEUROL, 50(3), 2001, pp. 301-311

Abstract

Two anti-neuronal nuclear antibodies (ANNA-1 and ANNA-2) are markers of paraneoplastic neurological autoimmunity related to small-cell carcinoma. ANNA-2 is also related to breast carcinoma. Here we define a third IgG specificity (ANNA-3), identified in 11 patients (10 adults) by immunofluorescence screening of sera from approximately 68,000 patients with suspected paraneoplastic neurological syndromes. ANNA-3 binds prominently to nuclei of cerebellar Purkinje neurons, not to cytoplasm, granular neurons, or enteric neurons, but distinctively to renal glomerular podocytes. Western blots revealed an approximately 170 kDa antigen, in cerebellum and small-cell carcinoma. IgG eluted from this protein reproduced Purkinje and podocyte nuclear staining. ANNA-2 in 8 of 32 cases bound to podocyte nuclei but not to the 170 kDa protein. Healthy subjects and control neurological and cancer patients lack ANNA-3. Neurological accompaniments, subacute and usually multifocal, included sensory/sensorimotor neuropathies, cerebellar ataxia, myelopathy, brain stem and limbic encephalopathy. All of 9 adults followed had an intrathoracic neoplasm, seven biopsied within 7 months (five small-cell lung carcinomas and two adenocarcinomas, one lung, one esophagus) and two imaged, one early, the other 3 years later. Thus, immunohistochemical and Western blot criteria can now identify six IgG markers of neurological autoimmunity related to small-cell carcinoma, their frequency being ANNA-1 > collapsin response-mediator protein-5 > amphiphysin > Purkinje cell cytoplasmic antibody-2 = ANNA-2 = ANNA-3.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:39:00