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Titolo:
Significance of the changes in the respiratory system pressure-volume curve during acute lung injury in rats
Autore:
Martin-Lefevre, L; Ricard, JD; Roupie, E; Dreyfuss, D; Saumon, G;
Indirizzi:
INSERM, U82, Fac Xavier Bichat, F-75870 Paris 18, France INSERM Paris France 18 U82, Fac Xavier Bichat, F-75870 Paris 18, France Hop Louis Mourier, Serv Reanimat Med, Assistance Publ Hop Paris, F-92701 Colombes, France Hop Louis Mourier Colombes France F-92701 aris, F-92701 Colombes, France Hop Henri Mondor, Assistance Publ Hop Paris, Serv Reanimat Med, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 mat Med, F-94010 Creteil, France
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 4, volume: 164, anno: 2001,
pagine: 627 - 632
SICI:
1073-449X(20010815)164:4<627:SOTCIT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
END-EXPIRATORY PRESSURE; INDUCED PULMONARY-EDEMA; HIGH TIDAL VOLUME; DISTRESS-SYNDROME; MECHANICAL VENTILATION; AIRWAY PRESSURE; RABBIT LUNGS; RECRUITMENT; MODEL; HYPERINFLATION;
Keywords:
ventilator-induced lung injury; respiratory mechanics; acute respiratory distress syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Saumon, G INSERM, U82, Fac Xavier Bichat, BP 416, F-75870 Paris 18, FranceINSERM BP 416 Paris France 18 BP 416, F-75870 Paris 18, France
Citazione:
L. Martin-Lefevre et al., "Significance of the changes in the respiratory system pressure-volume curve during acute lung injury in rats", AM J R CRIT, 164(4), 2001, pp. 627-632

Abstract

The hypothesis that the changes in the respiratory system pressure-volume (PV) curve during pulmonary edema mainly reflect distal airway obstruction was investigated in rats. Normal rats had a well-defined upper inflection point (UIP) at low airway pressure. Airway occlusion by liquid instillation decreased compliance (Crs) and the volume (Vuip) of the UIP, and increased end-inspiratory pressure. The same changes were observed during the progression of edema produced by high volume ventilation (HV). Changes in Vuip andin Crs produced by HV were correlated with edema severity in normal rats or rats with lungs preinjured with alpha -naphthylthiourea. Vuip and Crs changes were proportional, reflecting compression of the PV curve on the volume axis and suggesting reduction of the amount of ventilatable lung at low airway pressure. In keeping with this explanation, the lower Vuip and Crs were before HV, the more severe HV-induced edema was in alpha -naphthylthiourea-injected rats. When edema was profuse, PV curves displayed a marked lower inflection point (LIP), the UIP at low pressure disappeared but another was seen at high volume above the LIP, and the correlation between Vuip changes and edema severity was lost. These observations may have clinical relevance in the context of the "open lung" strategy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:40:18