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Titolo:
Fibrosing cholestatic hepatitis-like syndrome in hepatitis B virus-negative and hepatitis C virus-negative renal transplant recipients
Autore:
de Bustillo, EM; Benito, A; Colina, F; Andres, A; Dominguez-Gil, B; Munoz, MA; Rodicio, JL; Morales, JM;
Indirizzi:
Hosp Univ Doce Octubre, Dept Nephrol, Renal Transplant Unit, Madrid 28041,Spain Hosp Univ Doce Octubre Madrid Spain 28041 plant Unit, Madrid 28041,Spain Hosp Univ Doce Octubre, Dept Pathol, Madrid 28041, Spain Hosp Univ Doce Octubre Madrid Spain 28041 pt Pathol, Madrid 28041, Spain
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 3, volume: 38, anno: 2001,
pagine: 640 - 645
SICI:
0272-6386(200109)38:3<640:FCHSIH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER; INFECTION; AZATHIOPRINE; DISEASE;
Keywords:
fibrosing cholestatic hepatitis; hepatitis C virus (HCV); hepatitis B virus (HBV); renal transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Morales, JM Hosp Univ Doce Octubre, Dept Nephrol, Renal Transplant Unit, Carretera Andalucia Km 5400, Madrid 28041, Spain Hosp Univ Doce Octubre Carretera Andalucia Km 5400 Madrid Spain 28041
Citazione:
E.M. de Bustillo et al., "Fibrosing cholestatic hepatitis-like syndrome in hepatitis B virus-negative and hepatitis C virus-negative renal transplant recipients", AM J KIDNEY, 38(3), 2001, pp. 640-645

Abstract

Cholestatic hepatitis and diffuse liver fibrosis have been described in immunosuppressed patients with hepatitis B virus or hepatitis C virus infection as fibrosing cholestatic hepatitis (FCH). FCH is characterized by cholestasis, with only a modest Increase in aminotransferase levels. The pathologic picture typically shows periportal and perisinusoidal fibrosis, scarce mixed infiltrates, hepatocellular ballooning, and histologic cholestasis. Wereport two patients with diffuse fibrosis and cholestasis quite similar tothe histologic picture of FCH, but in whom neither hepatitis B virus nor hepatitis C virus infection could be shown, highlighting the potential contribution of cytomegalovirus Infection and azathioprine toxicity in the development of this severe complication of solid-organ transplantation. (C) 2001by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:21:57