Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Epidemiological evaluation of known and suspected cardiovascular risk factors in chronic renal impairment
Autore:
Landray, MJ; Thambyrajah, J; McGlynn, FJ; Jones, HJ; Baigent, C; Kendall, MJ; Townend, JN; Wheeler, DC;
Indirizzi:
Radcliffe Infirm, Clin Trial Serv Unit, Oxford OX2 6HE, England Radcliffe Infirm Oxford England OX2 6HE rv Unit, Oxford OX2 6HE, England Univ Birmingham, Div Med Sci, Birmingham B15 2TT, W Midlands, England UnivBirmingham Birmingham W Midlands England B15 2TT W Midlands, England Univ Hosp Birmingham NHS Trust, Dept Nephrol, Birmingham, W Midlands, England Univ Hosp Birmingham NHS Trust Birmingham W Midlands England ds, England Radcliffe Infirm, Epidemiol Studies Unit, Oxford OX2 6HE, England Radcliffe Infirm Oxford England OX2 6HE es Unit, Oxford OX2 6HE, England
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 3, volume: 38, anno: 2001,
pagine: 537 - 546
SICI:
0272-6386(200109)38:3<537:EEOKAS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA TOTAL HOMOCYSTEINE; DENSITY-LIPOPROTEIN CHOLESTEROL; SERUM CREATININE; DISEASE; FAILURE; APOLIPOPROTEINS; ATHEROSCLEROSIS; HEMODIALYSIS; PROGRESSION; PROFILES;
Keywords:
chronic renal impairment (CRI); vascular disease; lipids; homocysteine; hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Landray, MJ Radcliffe Infirm, Clin Trial Serv Unit, Hardness Bldg, Oxford OX2 6HE, England Radcliffe Infirm Hardness Bldg Oxford England OX2 6HE England
Citazione:
M.J. Landray et al., "Epidemiological evaluation of known and suspected cardiovascular risk factors in chronic renal impairment", AM J KIDNEY, 38(3), 2001, pp. 537-546

Abstract

Patients with chronic renal impairment (CRI) are at greatly increased riskfor premature vascular disease; however, little is known about its evolution. This paper describes a cohort of patients with CRI and reports study design, baseline demographic and biochemical data, and comparisons with two contemporaneous age- and sex-matched control groups, one with established coronary artery disease and the other without overt vascular disease. Among 369 individuals (median age, 63 years; range, 18 to 88 years; 67% men) with CRI, 34% had a history of vascular disease and 21% had electrocardiographicleft ventricular hypertrophy (LVH). Even in those with mild renal impairment (serum creatinine < 2.1 mg/dL), approximately one third had vascular disease and 12% had LVH. A history of hypertension was present in 76% of the CRI group, but as compared with controls, systolic and diastolic blood pressures were not elevated. Low-density lipoprotein (LDL) cholesterol concentration also was not elevated, but CRI was associated with elevated serum triglyceride and plasma homocysteine levels and reduced high-density lipoprotein (HDL) cholesterol, hemoglobin, and serum albumin concentrations. Across the spectrum of CRI, more severe renal dysfunction was associated with lowerlevels of diastolic blood pressure, LDL and HDL cholesterol, albumin, and hemoglobin, but increased levels of plasma homocysteine. This cross-sectional analysis shows that vascular disease is common in individuals with mild CRI attending a nephrology program and also suggests trends in the levels of a number of potential vascular risk factors with respect to severity of renal dysfunction. These results will be further quantified in a prospectivebiennial follow-up. (C) 2001 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/06/20 alle ore 17:41:59