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Titolo:
Heart failure, aging, and renal synthesis of dopamine
Autore:
Ferreira, A; Bettencourt, P; Pestana, M; Correia, F; Serrao, P; Martins, L; Cerqueira-Gomes, M; Soares-da-Silva, P;
Indirizzi:
Hosp Sao Joao, Serv Med 3, P-4200 Oporto, Portugal Hosp Sao Joao Oporto Portugal P-4200 Serv Med 3, P-4200 Oporto, Portugal Hosp Sao Joao, Serv Nefrol, P-4200 Oporto, Portugal Hosp Sao Joao OportoPortugal P-4200 erv Nefrol, P-4200 Oporto, Portugal Unidade Invest & Desenvolvimento Cardiovasc, Oporto, Portugal Unidade Invest & Desenvolvimento Cardiovasc Oporto Portugal o, Portugal Fac Med, Inst Pharmacol & Therapeut, Oporto, Portugal Fac Med Oporto Portugal d, Inst Pharmacol & Therapeut, Oporto, Portugal
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 3, volume: 38, anno: 2001,
pagine: 502 - 509
SICI:
0272-6386(200109)38:3<502:HFAARS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; PROXIMAL CONVOLUTED TUBULE; NA+-K+-ATPASE; ADENYLATE-CYCLASE; URINARY-EXCRETION; DA(1) RECEPTOR; SALT INTAKE; DISEASE; DIHYDROXYPHENYLALANINE; INHIBITION;
Keywords:
L-3,4-dihydroxyphenylalanine (L-dopa); dopamine; kidney; heart failure (HF);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Ferreira, A Hosp Sao Joao, Serv Med 3, Piso 8,Al Hernani Monteiro, P-4200 Oporto, Portugal Hosp Sao Joao Piso 8,Al Hernani Monteiro Oporto Portugal P-4200
Citazione:
A. Ferreira et al., "Heart failure, aging, and renal synthesis of dopamine", AM J KIDNEY, 38(3), 2001, pp. 502-509

Abstract

The present study evaluates renal dopaminergic activity in 23 patients with heart failure (NF), 10 age-matched controls, and 10 young subjects duringnormal-salt (NS) intake and after 8 days of low-salt (LS) intake (patientswith HF and age-matched controls only). LS intake produced a marked reduction in urine volume in patients with HF but failed to affect urine volume in age-matched controls. Urinary sodium and fractional excretion of sodium were markedly reduced by LS intake in patients with HF and age-matched controls. Daily urinary excretion of L-3,4-dihydroxyphenylalanine (L-dopa) and dopamine was lower in patients with HF than in age-matched controls. LS intake failed to alter L-dopa and dopamine urinary excretion in control subjects. In patients with HF, LS intake produced a significant decrease in urinary L-dopa excretion, but failed to alter the urinary excretion of dopamine. No significant differences were observed in urinary L-dopa, dopamine, and dopamine metabolite levels between aged controls and young healthy subjects. Urinary dopamine-L-dopa ratios in patients with HF on LS intake (24.5 +/- 7.1) were significantly greater than those with NS intake (11.6 +/- 1.3). Urinary dopamine-L-dopa ratios in old control subjects (LS, 9.7 +/- 1.3; NS,9.3 +/- 1.1) did not differ from those in young healthy subjects (9.2 +/- 0.8). LS intake produced a marked increase in plasma aldosterone levels in both patients with HF (84.6 +/- 14.4 to 148.2 +/- 20.4 pg/mL; P = 0.0008) and controls (102.1 +/- 13.4 to 151.6 +/- 15.7 pg/mL; P < 0.04). Plasma norepinephrine levels were not significantly affected by LS intake in controls (5.1 +/- 1.62 to 6.3 +/- 1.6 pmol/mL; P = 0.22), but were significantly increased in patients with HF (5.8 +/- 0.8 to 7.1 +/- 0.9 pmol/mL; P = 0.04). In conclusion, patients with HF are endowed with an enhanced ability to take up (or decarboxylate) filtered L-dopa, which might counterbalance the reduced renal delivery of L-dopa, contributing to a relative preservation of dopamine synthesis. This may result as a compensatory mechanism, activated by stimuli leading to sodium reabsorption. Age seems to have no influence onrenal dopamine production. (C) 2001 by the National Kidney Foundation, Inc.

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Documento generato il 30/05/20 alle ore 23:57:44