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Titolo:
Oral drug self-administration: an overview of laboratory animal studies
Autore:
Meisch, RA;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Psychiat & Behav Sci, Houston, TX 77030 USAUniv Texas Houston TX USA 77030 ychiat & Behav Sci, Houston, TX 77030 USA
Titolo Testata:
ALCOHOL
fascicolo: 2, volume: 24, anno: 2001,
pagine: 117 - 128
SICI:
0741-8329(200106)24:2<117:ODSAOO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALTERNATIVE NONDRUG REINFORCER; PROGRESSIVE-RATIO SCHEDULES; BEHAVIORAL ECONOMIC-ANALYSIS; RHESUS-MONKEYS; FOOD-DEPRIVATION; DELIVERED PHENCYCLIDINE; FIXED-RATIO; FEEDING CONDITIONS; CONCURRENT PHENCYCLIDINE; NALTREXONE PRETREATMENT;
Keywords:
drug self-administration; drug reinforcement; overview; dose; schedule of reinforcement; taste; food restriction; acquisition; choice; relative reinforcing effects; oral route;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
133
Recensione:
Indirizzi per estratti:
Indirizzo: Meisch, RA Univ Texas, Hlth Sci Ctr, Dept Psychiat & Behav Sci, 1300 Moursund, Houston, TX 77030 USA Univ Texas 1300 Moursund Houston TX USA 77030 ton, TX 77030 USA
Citazione:
R.A. Meisch, "Oral drug self-administration: an overview of laboratory animal studies", ALCOHOL, 24(2), 2001, pp. 117-128

Abstract

Many abused drugs can be established as orally delivered reinforcers for rhesus monkeys and other animals. Benzodiazepines, barbiturates, opioids, psychomotor stimulants, dissociative anesthetics, and ethanol can come to serve as reinforcers when taken by mouth. The principal problems in establishing drugs as reinforcers by the oral route of administration are (1) aversive taste, (2) delay in onset of central nervous system effects, and (3) consumption of low volumes of drug solution. Strategies have been devised to successfully overcome these problems, and orally delivered drugs can be established as effective reinforcers. Reinforcing actions are demonstrated by consumption of greater volumes of drug solution than volumes of the water vehicle, and supporting evidence for reinforcing effects consists of the maintenance of behavior under intermittent schedules of reinforcement and the generation of orderly dose-response functions. This article presents an overview of studies of behavior reinforced by oral drug reinforcement. Factors that control oral drug intake include dose, schedule of reinforcement, food restriction, and alternative reinforcers. Many drugs, administered by the experimenter, can alter oral drug reinforcement. Relative reinforcing effects can be assessed by choice procedures and by persistence of behavior across increases in schedule size. In general, reinforcing effects increase directly with dose. Rhesus monkeys prefer combinations of reinforcing drugs to the component drugs. The taste of drug solutions may act as a conditioned reinforcer and a discriminative stimulus. Consequences of drug intake include tolerance and physiological dependence. Findings with orally self-administered drugs are similar to many findings with other positive reinforcers, including intravenously self-administered drugs. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 23/01/20 alle ore 07:23:34