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Titolo:
Neurobiological mechanisms of nicotine craving
Autore:
Miyata, H; Yanagita, T;
Indirizzi:
Jikei Univ, Sch Med, Dept Psychiat, Minato Ku, Tokyo 1058461, Japan Jikei Univ Tokyo Japan 1058461 Psychiat, Minato Ku, Tokyo 1058461, Japan Jikei Univ, Sch Med, Dept Pharmacol 1, Minato Ku, Tokyo 1058461, Japan Jikei Univ Tokyo Japan 1058461 rmacol 1, Minato Ku, Tokyo 1058461, Japan
Titolo Testata:
ALCOHOL
fascicolo: 2, volume: 24, anno: 2001,
pagine: 87 - 93
SICI:
0741-8329(200106)24:2<87:NMONC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULUS REWARD ASSOCIATIONS; CONDITIONED PLACE PREFERENCE; OPPONENT-PROCESS THEORY; BASOLATERAL AMYGDALA; EXCITOTOXIC LESIONS; WITHDRAWAL SYNDROME; 2ND-ORDER SCHEDULE; TOBACCO WITHDRAWAL; PREFRONTAL CORTEX; OPIATE WITHDRAWAL;
Keywords:
nicotine; drug dependence; craving; reward systems; withdrawal; environmental stimuli;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Miyata, H Jikei Univ, Sch Med, Dept Psychiat, Minato Ku, 3-25-8 Nishishimbashi, Tokyo 1058461, Japan Jikei Univ 3-25-8 Nishishimbashi Tokyo Japan 1058461 461, Japan
Citazione:
H. Miyata e T. Yanagita, "Neurobiological mechanisms of nicotine craving", ALCOHOL, 24(2), 2001, pp. 87-93

Abstract

Nicotine induces craving, but the degree of craving is believed to be milder than that with other abused drugs. In this article, the neurobiological mechanisms of craving for nicotine and other drugs are reviewed, focusing especially on three factors that can be involved in the development of craving. The first factor is the affective symptoms of withdrawal, the neural basis of which may involve neuroadaptations (desensitization) within the reward systems. Affective symptoms experienced during withdrawal from nicotine are milder than those experienced in withdrawal from other drugs, probably because of its mode of action on the reward systems, which is similar to that of natural rewards. The second factor is the conditioning process, in which environmental stimuli can gain properties of a secondary reinforcer. Nicotine has weak but reliable conditioning effects, and the brain region mediating those effects of nicotine involves the ventral tegmental area. The third factor is a cognitive (memory) process, but little is known about thisarea. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:19:48