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Titolo:
Advances in antibody catalysis of cycloaddition reactions
Autore:
Tremblay, MR; Dickerson, TJ; Janda, KD;
Indirizzi:
Scripps Clin & Res Inst, Dept Chem, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 hem, La Jolla, CA 92037 USA Skaggs Inst Chem Biol, La Jolla, CA 92037 USA Skaggs Inst Chem Biol La Jolla CA USA 92037 Biol, La Jolla, CA 92037 USA
Titolo Testata:
ADVANCED SYNTHESIS & CATALYSIS
fascicolo: 6-7, volume: 343, anno: 2001,
pagine: 577 - 585
SICI:
1615-4150(200108)343:6-7<577:AIACOC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIELS-ALDER REACTION; SHAPE COMPLEMENTARITY; PERICYCLIC-REACTIONS; INPLANE AROMATICITY; ENANTIOSELECTIVITY; REGIOSELECTIVITY; BINDING; PATHWAY; H11;
Keywords:
catalytic antibodies; cycloaddition; Diels-Alder reaction; 1,3-dipolar cycloaddition;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Janda, KD Scripps Clin & Res Inst, Dept Chem, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA Scripps Clin & Res Inst 10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
M.R. Tremblay et al., "Advances in antibody catalysis of cycloaddition reactions", ADV SYNTH C, 343(6-7), 2001, pp. 577-585

Abstract

Pericyclic cycloaddition reactions are among the most useful transformations available to the synthetic organic chemist. All are capable of simultaneously establishing multiple stereogenic centers with high levels of selectivity. Although many powerful chemical catalysts for these reactions exist, biological catalysts for these reactions are rare, and in most cases, non-existent. With the advent of catalytic antibody technology, proteins have been developed that are capable of not only catalyzing the Diels-Alder reaction, but also hetero-Diels-Alder, retro-Diels-Alder, and 1,3-dipolar cycloaddition reactions. This review will summarize the key developments in the use or catalytic antibodies as catalysts for these powerful cycloaddition reactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:25:22