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Titolo:
Rapid induction of meningeal collagen synthesis in the cerebral cisternal and ventricular compartments after subarachnoid hemorrhage
Autore:
Sajanti, J; Heikkinen, E; Majamaa, K;
Indirizzi:
Univ Oulu, Dept Neurol, FIN-90014 Oulu, Finland Univ Oulu Oulu Finland FIN-90014 u, Dept Neurol, FIN-90014 Oulu, Finland Univ Oulu, Dept Neurosurg, FIN-90014 Oulu, Finland Univ Oulu Oulu Finland FIN-90014 Dept Neurosurg, FIN-90014 Oulu, Finland Univ Oulu, Dept Med Biochem, FIN-90014 Oulu, Finland Univ Oulu Oulu Finland FIN-90014 pt Med Biochem, FIN-90014 Oulu, Finland
Titolo Testata:
ACTA NEUROCHIRURGICA
fascicolo: 8, volume: 143, anno: 2001,
pagine: 821 - 826
SICI:
0001-6268(2001)143:8<821:RIOMCS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PULMONARY FIBROSIS; CEREBROSPINAL-FLUID; TRANSFORMING GROWTH-FACTOR-BETA-1; COMMUNICATING HYDROCEPHALUS; PROCOLLAGEN PROPEPTIDES; BLEOMYCIN; INCREASE; FIBRONECTIN; DEPOSITION; CYTOKINES;
Keywords:
cerebrospinal fluid; diagnosis; fibrosis; leptomeninges;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Majamaa, K Univ Oulu, Dept Neurol, POB 5000, FIN-90014 Oulu, Finland Univ Oulu POB 5000 Oulu Finland FIN-90014 -90014 Oulu, Finland
Citazione:
J. Sajanti et al., "Rapid induction of meningeal collagen synthesis in the cerebral cisternal and ventricular compartments after subarachnoid hemorrhage", ACT NEUROCH, 143(8), 2001, pp. 821-826

Abstract

Procollagen propeptides in the lumbar CSF increase after subarachnoid hemorrhage (SAH), and elevated concentrations have been detected as early as onday 8. We studied here the timing and localization of the induction of meningeal collagen synthesis during the first week after SAH by analysing cisternal and ventricular CSF samples. We obtained 29 cisternal and 10 ventricular CSF samples at operation from patients with SAH between days 1 and 9 after onset. The carboxyterminal propeptide of type I procollagen (PICP) and the aminoterminal propeptide of type III procollagen (PIIINP) were measuredusing radio-immunoassays. The concentrations of PICP and PIIINP in the cisternal CSF were elevated as early as on day 2 after SAH, PICP increased in a sigmoidal fashion (R-2 = 0.39, p < 0.001), while PIIINP increased linearly (R-2 = 0.28, p = 0.003) and was approximately 3-fold higher on day 9 thaninitially. PICP was twice as high (p = 0.02) in the cisternal than in the ventricular CSF after SAH and PIIINP was 4-times higher (p = 0.007). Interestingly, the concentrations were similar in a patient with intraventricularbleeding. The cisternal compartment contributed to the propeptides in the CSF more than did the ventricular compartment, but the latter also appearedto have a definite potential for fibroproliferative reaction. Meningeal collagen synthesis was induced rapidly within the first few days after SAH suggesting that therapeutic attempts to inhibit the fibroproliferative reaction should be started as early as possible.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 05:44:08