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Titolo:
Bench to bedside: Resuscitation from prolonged ventricular fibrillation
Autore:
Angelos, MG; Menegazzi, JJ; Callaway, CW;
Indirizzi:
Ohio State Univ, Dept Emergency Med, Prior Hlth Sci Lib 016, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 Sci Lib 016, Columbus, OH 43210 USA Univ Pittsburgh, Dept Emergency Med, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA Dept Emergency Med, Pittsburgh, PA USA
Titolo Testata:
ACADEMIC EMERGENCY MEDICINE
fascicolo: 9, volume: 8, anno: 2001,
pagine: 909 - 924
SICI:
1069-6563(200109)8:9<909:BTBRFP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASPHYXIAL CARDIAC-ARREST; POSTRESUSCITATION MYOCARDIAL DYSFUNCTION; GLUCOSE-INSULIN-POTASSIUM; BIPHASIC WAVE-FORMS; POSTISCHEMIC STUNNED MYOCARDIUM; FREE-RADICAL GENERATION; DELAYED NEURONAL DEATH; SENSITIVE K+ CHANNELS; HIGH-DOSE EPINEPHRINE; ISOLATED RAT HEARTS;
Keywords:
ventricular fibrillation; cardiac arrest; resuscitation; heart; brain;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
154
Recensione:
Indirizzi per estratti:
Indirizzo: Angelos, MG Ohio State Univ, Dept Emergency Med, Prior Hlth Sci Lib 016, 376 W 10th Ave, Columbus, OH 43210 USA Ohio State Univ 376 W 10th Ave Columbus OH USA 43210 43210 USA
Citazione:
M.G. Angelos et al., "Bench to bedside: Resuscitation from prolonged ventricular fibrillation", ACAD EM MED, 8(9), 2001, pp. 909-924

Abstract

Ventricular fibrillation (VF) remains the most common cardiac arrest heartrhythm. Defibrillation is the primary treatment and is very effective if delivered early within a few minutes of onset of VF. However, successful treatment of VF becomes increasingly more difficult when the duration of VF exceeds 4 minutes. Classically, successful cardiac arrest resuscitation has been thought of as simply achieving restoration of spontaneous circulation (ROSC). However, this traditional approach fails to consider the high early post-cardiac arrest mortality and morbidity and ignores the reperfusion injuries, which are manifest in the heart and brain. More recently, resuscitation from cardiac arrest has been divided into two phases; phase I, achieving ROSC, and phase II, treatment of reperfusion injury. The focus in both phases of resuscitation remains the heart and brain, as prolonged VF remains primarily a two-organ disease. These two organs are most sensitive to oxygen and substrate deprivation and account for the vast majority of early post-resuscitation mortality and morbidity. This review focuses first on the initial resuscitation (achieving ROSC) and then on the reperfusion issues affecting the heart and brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:40:09