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Titolo:
Tachykinins as modulators of the micturition reflex in the central and peripheral nervous system
Autore:
Lecci, A; Maggi, CA;
Indirizzi:
Menarini Ric, Dept Pharmacol, I-50131 Florence, Italy Menarini Ric Florence Italy I-50131 t Pharmacol, I-50131 Florence, Italy
Titolo Testata:
REGULATORY PEPTIDES
fascicolo: 1-3, volume: 101, anno: 2001,
pagine: 1 - 18
SICI:
0167-0115(20010915)101:1-3<1:TAMOTM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT URINARY-BLADDER; GENE-RELATED PEPTIDE; PRIMARY SENSORY NEURONS; NORMAL CONSCIOUS RATS; GUINEA-PIG BLADDER; NK1 RECEPTOR ANTAGONIST; SPINAL-CORD INJURY; CYCLASE ACTIVATING POLYPEPTIDE; SENSITIVE PRIMARY AFFERENTS; URETHANE-ANESTHETIZED RATS;
Keywords:
tachykinin antagonists; NK1 receptors; NK2 receptors; NK3 receptors; urinary bladders; urethra; capsaicin; visceral pain;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
176
Recensione:
Indirizzi per estratti:
Indirizzo: Lecci, A Menarini Ric, Dept Pharmacol, Via Rismondo 12-A, I-50131 Florence, Italy Menarini Ric Via Rismondo 12-A Florence Italy I-50131 nce, Italy
Citazione:
A. Lecci e C.A. Maggi, "Tachykinins as modulators of the micturition reflex in the central and peripheral nervous system", REGUL PEPT, 101(1-3), 2001, pp. 1-18

Abstract

In the normal urinary bladder, tachykinins (TKs) are expressed in a population of bladder nociceptors that is sensitive to the excitatory and desensitizing effects of capsaicin (i.e., capsaicin-sensitive primary afferent neurons (CSPANs)). Several endobiotics or xenobiotics excite CSPANs and release TKs and other mediators at both the peripheral and spinal cord level. Theperipheral release of TKs determines a set of responses (known as neurogenic inflammation) that includes vasodilatation. plasma protein extravasation, smooth muscle contraction and stimulation of afferent nerves. Following chronic inflammation, both immune cells and capsaicin-resistant sensory neurons can de novo express TKs: whether these pools of TKs are releasable and contribute to inflammatory processes is presently unsettled. At the spinal cord level. the release of TKs contributes in determining an altered pattern of vesicourethral reflexes in response to nociceptive stimulation of the bladder by conveying: (a) the afferent transmission to supraspinal sites. and (b) descending or sensory inputs to the sacral parasympathetic nucleus (SPN). Recent evidence also attribute a synergetic role of TKs in the supraspinal modulation of the sensory arm of the micturition reflex. The overall available information suggests that TK receptor antagonists may affect bladder motility/reflexes which occur during different pathological states, while having little influence on the normal motor bladder function. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 21:56:43