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Titolo:
Pituitary LH reserve suggests high risk of bulimia in amenorrheic women
Autore:
Nappi, RE; Neri, I; Veneroni, F; Polatti, F; Piccinini, F; Facchinetti, F;
Indirizzi:
Univ Pavia, Policlin San Matteo, IRCCS, Dept Obstet & Gynecol, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 pt Obstet & Gynecol, I-27100 Pavia, Italy Univ Moden & Reggio, Dept Gynecol Obstet & Pediat Sci, Emilia, Italy Univ Moden & Reggio Emilia Italy col Obstet & Pediat Sci, Emilia, Italy
Titolo Testata:
PSYCHONEUROENDOCRINOLOGY
fascicolo: 7, volume: 26, anno: 2001,
pagine: 721 - 730
SICI:
0306-4530(200110)26:7<721:PLRSHR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL HYPOTHALAMIC AMENORRHEA; LUTEINIZING-HORMONE RELEASE; POLYCYSTIC-OVARY-SYNDROME; BINGE-EATING DISORDER; ANOREXIA-NERVOSA; BETA-ENDORPHIN; REPRODUCTIVE FUNCTION; WEIGHT-LOSS; FOLLOW-UP; NALTREXONE;
Keywords:
amenorrhea; bulimia; BITE; pituitary; gonadotropins; BMI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Nappi, RE Univ Pavia, Policlin San Matteo, IRCCS, Dept Obstet & Gynecol, Piazzale Golgi 2, I-27100 Pavia, Italy Univ Pavia Piazzale Golgi 2 Pavia Italy I-27100 00 Pavia, Italy
Citazione:
R.E. Nappi et al., "Pituitary LH reserve suggests high risk of bulimia in amenorrheic women", PSYCHONEURO, 26(7), 2001, pp. 721-730

Abstract

The present study was aimed at investigating a) the risk of having bulimiain a heterogeneous population of secondary amenorrhea; b) the LH and FSH secretion under basal and stimulated conditions (GnRH challenge) according to the presence of bulimic risk in our study population; c) the clinical andendocrine factors predictive of the bulimic risk in amenorrheic women. Amenorrheic women (n=73; age: 23.1 +/-4.8 yrs; BMI:20.2 +/-2.2 kg/m(2)) filled in a self rating scale for bulimia (BITE) and were classified accordingly, as being at low risk (score < 10), at medium risk (score between 10 and 24), and at high risk (score greater than or equal to 25) of having bulimia. In each subject basal mean plasma LH levels were calculated over one hour, sampling every 10 minutes, while in a subgroup of 45 patients the area under the curve (AUC) of plasma LH and FSH levels following a challenge with two doses of GnRH (10+10 mug, every two hours), sampling every 15 minutes, was also evaluated. High risk of bulimia was present in 12.3% of the population whereas 45.2% showed a low risk and 42.5% were at medium risk of developing the disorder. Mann-Whitney U test revealed that basal LH values were differently distributed with significantly lower levels (P <0.046) in amenorrheic women at high risk of bulimia in comparison with amenorrheic women at low risk. The AUCof LH secretion following the first challenge of GnRH was significantly higher in amenorrheic women with a high risk of bulimia in respect with both groups of women at low (P <0.034) and medium (P <0.009) risk. A similar result was found with FSH AUC following the first GnRH challenge (P <0.04 highrisk vs low risk and medium risk). In a multiple regression analysis, the best model predicting the risk of bulimia (BITE total score) included both the LH response to GnRH challenge and BMI. In conclusion, when facing secondary amenorrhea at first consultation, long before a precise pathophysiologic diagnosis of the disease, low basal plasma LH levels and LH response to GnRH challenge may allow one to suspect the presence of abnormal eating pattern of bulimic type. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 07:02:58