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Titolo:
Mapping cortical asymmetry and complexity patterns in normal children
Autore:
Blanton, RE; Levitt, JG; Thompson, PM; Narr, KL; Capetillo-Cunliffe, L; Nobel, A; Singerman, JD; McCracken, JT; Toga, AW;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Neurol, Div Brain Mapping,Lab Neuro Imaging, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Div Child Psychiat, Los Angeles, CA 90095USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095USA
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 1, volume: 107, anno: 2001,
pagine: 29 - 43
SICI:
0925-4927(20010701)107:1<29:MCAACP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE IMAGES; HUMAN-BRAIN; CEREBRAL ASYMMETRY; PARS TRIANGULARIS; PLANUM TEMPORALE; SYLVIAN FISSURE; SPEECH REGION; IN-VIVO; SURFACE; MORPHOLOGY;
Keywords:
imaging; cerebral cortex; development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Toga, AW Univ Calif Los Angeles, Sch Med, Dept Neurol, Div Brain Mapping,Lab Neuro Imaging, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 es, CA 90095 USA
Citazione:
R.E. Blanton et al., "Mapping cortical asymmetry and complexity patterns in normal children", PSYCH RES-N, 107(1), 2001, pp. 29-43

Abstract

This study reports the first comprehensive three-dimensional (3D) maps of cortical patterns in children. Using a novel parametric mesh-based analytictechnique applied to high-resolution Tl-weighted MRI scans, we examined age (6-16 years) and gender differences in cortical complexity (the fractal dimension or complexity of sulcal/gyral convolutions) and asymmetry of 24 primary cortical sulci in normally developing children (N = 24). Three-dimensional models of the cerebral cortex were extracted and major sulci mapped in stereotaxic space. Given the documented age-related changes in frontal lobe functions and several neuroimaging studies that have reported accompanying volumetric changes in these regions, we hypothesized that, with age, we would find continued modifications of the cerebrum in frontal cortex. We also predicted that phylogenetically older regions of the cerebrum, such as olfactory cortex, would be less variable in anatomic location across subjects and with age. Age-related increases in cortical complexity were found in both left and right inferior frontal and left superior frontal regions, possibly indicating an increase in secondary branching with age in these regions. Moreover, a significant increase in the length of the left inferior frontal sulcus and a posterior shifting of the left pre-central sulcus was associated with age. Three-dimensional asymmetry and anatomic variability mapsrevealed a significant left-greater-than-right asymmetry of the Sylvian fissures and superior temporal sulci, and increased variance in dorsolateral frontal and perisylvian areas relative to ventral regions of the cortex. These results suggest increases in cortical complexity and subtle modifications of sulcal topography of frontal lobe regions, likely reflecting ongoing processes such as myelination and synaptic remodeling that continue into the second decade of life. More studies in a larger sample set and/or longitudinal design are needed to address the issues of normal individual variation and sulcal development. (C) 2001 Elsevier Science Ireland Ltd. All rightsreserved.

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Documento generato il 22/01/20 alle ore 06:34:55