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Titolo:
High frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral cortex: EEG topography during waking and subsequent sleep
Autore:
Graf, T; Engeler, J; Achermann, P; Mosimann, UP; Noss, R; Fisch, HU; Schlaepfer, TE;
Indirizzi:
Univ Hosp Bern, Psychiat Neuroimaging Grp, CH-3010 Bern, Switzerland Univ Hosp Bern Bern Switzerland CH-3010 g Grp, CH-3010 Bern, Switzerland Univ Zurich, Inst Pharmacol & Toxicol, Zurich, Switzerland Univ Zurich Zurich Switzerland Pharmacol & Toxicol, Zurich, Switzerland
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 1, volume: 107, anno: 2001,
pagine: 1 - 9
SICI:
0925-4927(20010701)107:1<1:HFRTMS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREFRONTAL CORTEX; ELECTROMAGNETIC-FIELD; MOOD; DEPRESSION; ELECTROENCEPHALOGRAM; EFFICACY; SAFETY;
Keywords:
repetitive transcranial magnetic stimulation; brain stimulation; sleep EEG; waking EEG; spectral analysis; polysomnography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Schlaepfer, TE Univ Hosp Bern, Psychiat Neuroimaging Grp, Murtenstr 21, CH-3010 Bern, Switzerland Univ Hosp Bern Murtenstr 21 Bern Switzerland CH-3010 rland
Citazione:
T. Graf et al., "High frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral cortex: EEG topography during waking and subsequent sleep", PSYCH RES-N, 107(1), 2001, pp. 1-9

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a novel research tool in neurology and psychiatry. It is currently being evaluated as a conceivable alternative to electroconvulsive therapy for the treatment of mood disorders. Eight healthy young (age range 21-25 years) right-handed men without sleep complaints participated in the study. Two sessions at a 1-week interval. each consisting of an adaptation night (sham stimulation) and an experimental night (rTMS in the left dorsolateral prefrontal cortex or sham stimulation; crossover design), were scheduled. In each subject, 40 trains of2-s duration of rTMS (inter-train interval 28 s) were applied at a frequency of 20 Hz (i.e. 1600 pulses per session) and at an intensity of 90% of the motor threshold. Stimulations were scheduled 80 min before lights off. The waking EEG was recorded for 10-min intervals similar to 30 min prior to and after the 20-min stimulations, and polysomnographic recordings were obtained during the subsequent sleep episode (23.00-07.00 h). The power spectraof two referential derivations, as well as of bipolar derivations along the antero-posterior axis over the left and right hemispheres, were analyzed.rTMS induced a small reduction of sleep stage 1 (in min and percentage of total sleep time) over the whole night and a small enhancement of sleep stage 4 during the first non-REM sleep episode. Other sleep variables were notaffected. rTMS of the left dorsolateral cortex did not alter the topography of EEG power spectra in waking following stimulation, in the all-night sleep EEG, or during the first non-REM sleep episode. Our results indicate that a single session of rTMS using parameters like those used in depression treatment protocols has no detectable side effects with respect to sleep inyoung healthy males. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 09:02:09