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Titolo:
Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways
Autore:
Yager, J; Richards, S; Hekmat-Scafe, DS; Hurd, DD; Sundaresan, V; Caprette, DR; Saxton, WM; Carlson, JR; Stern, M;
Indirizzi:
Rice Univ, Dept Biochem & Cell Biol, Houston, TX 77005 USA Rice Univ Houston TX USA 77005 Biochem & Cell Biol, Houston, TX 77005 USA Indiana Univ, Dept Biol, Bloomington, IN 47405 USA Indiana Univ Bloomington IN USA 47405 ept Biol, Bloomington, IN 47405 USA Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 ular & Dev Biol, New Haven, CT 06520 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 18, volume: 98, anno: 2001,
pagine: 10445 - 10450
SICI:
0027-8424(20010828)98:18<10445:CODPGG>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROFIBROMATOSIS TYPE-1 GENE; SCHWANN-CELLS; NEURONAL EXCITABILITY; MUTATIONS; MUTANT; PROTEIN; IDENTIFICATION; MELANOGASTER; TRANSMISSION; FIBROBLASTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Stern, M Rice Univ, Dept Biochem & Cell Biol, MS-140, Houston, TX 77005 USA Rice Univ MS-140 Houston TX USA 77005 -140, Houston, TX 77005 USA
Citazione:
J. Yager et al., "Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways", P NAS US, 98(18), 2001, pp. 10445-10450

Abstract

Drosophila peripheral nerves, similar structurally to the peripheral nerves of mammals, comprise a layer of axons and inner glia, surrounded by an outer perineurial glial layer. Although it is well established that intercellular communication occurs among cells within peripheral nerves, the signaling pathways used and the effects of this signaling on nerve structure and function remain incompletely understood. Here we demonstrate with genetic methods that the Drosophila peripheral nerve is a favorable system for the study of intercellular signaling. We show that growth of the perineurial gliais controlled by interactions among five genes: ine, which encodes a putative neurotransmitter transporter; eag, which encodes a potassium channel; push, which encodes a large, Zn(2+-)finger-containing protein; amn, which encodes a putative neuropeptide related to the pituitary adenylate cyclase activator peptide; and NF1, the Drosophila ortholog of the human gene responsible for type 1 neurofibromatosis. In other Drosophila systems, push and NF1 are required for signaling pathways mediated by Amn or the pituitary adenylate cyclase activator peptide. Our results support a model in which the Amn neuropeptide, acting through Push and NF1, inhibits perineurial glial growth, whereas the substrate neurotransmitter of Ine promotes perineurial glial growth. Defective intercellular signaling within peripheral nerves might underlie the formation of neurofibromas, the hallmark of neurofibromatosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 04:56:13