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Titolo:
A new mathematical model of dynamic cerebral autoregulation based on a flow dependent feedback mechanism
Autore:
Kirkham, SK; Craine, RE; Birch, AA;
Indirizzi:
Univ Southampton, Fac Math Studies, Southampton SO17 1BJ, Hants, England Univ Southampton Southampton Hants England SO17 1BJ 7 1BJ, Hants, England Southampton Univ Hosp NHS Trust, Dept Med Phys & Bioengn, Southampton SO166YD, Hants, England Southampton Univ Hosp NHS Trust Southampton Hants England SO16 6YD ngland
Titolo Testata:
PHYSIOLOGICAL MEASUREMENT
fascicolo: 3, volume: 22, anno: 2001,
pagine: 461 - 473
SICI:
0967-3334(200108)22:3<461:ANMMOD>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL BLOOD-PRESSURE; FREQUENCY-DOMAIN ANALYSIS; TRANSCRANIAL DOPPLER; VALSALVA MANEUVER; SPONTANEOUS FLUCTUATIONS; HUMANS; VELOCITY;
Keywords:
cerebral autoregulation; cerebral blood flow; mathematical modelling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kirkham, SK Univ Southampton, Fac Math Studies, Southampton SO17 1BJ, Hants, England Univ Southampton Southampton Hants England SO17 1BJ , England
Citazione:
S.K. Kirkham et al., "A new mathematical model of dynamic cerebral autoregulation based on a flow dependent feedback mechanism", PHYSL MEAS, 22(3), 2001, pp. 461-473

Abstract

A new mathematical model representing dynamic cerebral autoregulation as aflow dependent feedback mechanism is presented. Two modelling parameters are introduced, lambda, the rate of restoration, and tau, a time delay. Velocity profiles are found for a general arterial blood pressure, allowing themodel to be applied to any experiment that uses changes in arterial blood pressure to assess dynamic cerebral autoregulation. Two such techniques, thigh cuffs and a lower body negative pressure box, which produce step changes and oscillatory variations in arterial blood pressure respectively, are investigated. Results derived using the mathematical model are compared withdata from the two experiments. The comparisons yield similar estimates forlambda and tau, suggesting these parameters are independent of the pressure change stimulus and depend only on the main features of the dynamic cerebral autoregulation process. The modelling also indicates that for imposed oscillatory variations in arterial blood pressure a small phase difference between pressure and velocity waveforms does not necessarily imply impaired autoregulation. It is shown that the ratio between the variation in maximumvelocity and pressure variation can be used, along with the phase difference, to indicate the nature of the autoregulatory response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:05:27