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Titolo:
Interferon-gamma and interleukin-10 production among HIV-1-Infected and uninfected infants of HIV-1-infected mothers
Autore:
Kuhn, L; Coutsoudis, A; Moodley, D; Mngqundaniso, N; Trabattoni, D; Shearer, GM; Clerici, M; Coovadia, HM;
Indirizzi:
Columbia Univ, Coll Phys & Surg, Gertrude H Sergievsky Ctr, New York, NY 10032 USA Columbia Univ New York NY USA 10032 ergievsky Ctr, New York, NY 10032 USA Columbia Univ, Joseph H Mailman Sch Publ Hlth, Div Epidemiol, New York, NY10032 USA Columbia Univ New York NY USA 10032 Div Epidemiol, New York, NY10032 USA Univ Natal, Dept Paediat & Child Hlth, ZA-4001 Durban, South Africa Univ Natal Durban South Africa ZA-4001 lth, ZA-4001 Durban, South Africa Univ Milan, Cattedra Immunol, I-20122 Milan, Italy Univ Milan Milan Italy I-20122 n, Cattedra Immunol, I-20122 Milan, Italy NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA20892 xpt Immunol Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
PEDIATRIC RESEARCH
fascicolo: 3, volume: 50, anno: 2001,
pagine: 412 - 416
SICI:
0031-3998(200109)50:3<412:IAIPAH>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; T-LYMPHOCYTE ACTIVITY; HIV-INFECTION; DISEASE PROGRESSION; TYPE-1 TRANSMISSION; PERIPHERAL-BLOOD; CHILDREN BORN; CELL ACTIVITY; SOUTH-AFRICA; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kuhn, L Columbia Univ, Coll Phys & Surg, Gertrude H Sergievsky Ctr, 630 W 168th St, New York, NY 10032 USA Columbia Univ 630 W 168th St New York NY USA 10032 k, NY 10032 USA
Citazione:
L. Kuhn et al., "Interferon-gamma and interleukin-10 production among HIV-1-Infected and uninfected infants of HIV-1-infected mothers", PEDIAT RES, 50(3), 2001, pp. 412-416

Abstract

Immunologic consequences of exposure to HIV-1 in utero are still poorly understood. This study investigates relationships between type-l [interferon-gamma (IFN-gamma)] and type-2 (IL-10) cytokine production and maternal-infant HIV-1 transmission. Cord blood leukocytes from deliveries of 71 HIV-1-infected and 11 uninfected mothers were tested for in vitro IFN-gamma and IL-10 production after phytohemagglutinin (PHA) stimulation. The infants of these HIV-1-infected mothers were followed prospectively after birth to determine HIV vertical transmission, and IFN-gamma and IL-10 production was measured again at 6 mo. Median PHA-stimulated IFN-gamma production was 210 pg/mL in cord blood cells from infected and 73 pg/mL from uninfected mothers (p= 0.12), and median PHA-stimulated IL-10 production was 491 pg/mL in cord blood cells from infected and 161 pg/mL from uninfected mothers (p = 0.004). PHA-stimulated IFN-gamma and IL-10 production alone were not significantly associated with transmission, but relationships between the two cytokinesdiffered among infected and uninfected infants of HIV-1-infected mothers. PRA-stimulated IFN-gamma and IL-10 production was positively correlated among infected (r = 0.7, p = 0.12 in cord blood and r = 0.66, p = 0.03 at 6 mo) but not uninfected infants, and stronger relative production of IFN-gammato IL-10 was observed among exposed uninfected than among infected infants(p = 0.04). Exposure in utero to HIV-1 may augment production of IL-10 detectable in fetal cord blood. Stronger relative production of IFN-gamma to IL-10 in cord blood cells from infants of HIV-1-infected mothers may be associated with protection against perinatal HIV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:25:11