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Titolo:
The renal hemodynamic effects of Aspirin in newborn and young adult rabbits
Autore:
Drukker, A; Mosig, D; Guignard, JP;
Indirizzi:
CHUV, Univ Med Ctr, Dept Pediat, Div Pediat Nephrol, CH-1011 Lausanne, Switzerland CHUV Lausanne Switzerland CH-1011 Nephrol, CH-1011 Lausanne, Switzerland
Titolo Testata:
PEDIATRIC NEPHROLOGY
fascicolo: 9, volume: 16, anno: 2001,
pagine: 713 - 718
SICI:
0931-041X(200109)16:9<713:TRHEOA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PATENT DUCTUS-ARTERIOSUS; PROSTAGLANDIN SYNTHESIS; INDOMETHACIN; IBUPROFEN; KIDNEY; EXPOSURE; CLOSURE; INHIBITORS; INFANTS; FAILURE;
Keywords:
kidney function; neonate; prostaglandins; Aspirin; non-steroidal anti-inflammatory drugs; cyclooxygenases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Guignard, JP CHUV, Univ Med Ctr, Dept Pediat, Div Pediat Nephrol, CH-1011 Lausanne, Switzerland CHUV Lausanne Switzerland CH-1011 011 Lausanne, Switzerland
Citazione:
A. Drukker et al., "The renal hemodynamic effects of Aspirin in newborn and young adult rabbits", PED NEPHROL, 16(9), 2001, pp. 713-718

Abstract

A group of neonatal (n=10) and 12-week-old (n=12) anesthetized, ventilatedNew Zealand white rabbits received an acute i.v. dose (40 mg/kg body weight) of acetylsalicylic acid (ASA, Aspirin). In the neonatal animals, i.v. ASA caused within 20 min a significant (P<0.01) fall in renal blood flow and glomerular filtration rate (GFR), with an equally significant (P<0.01) increase in filtration fraction and renal vascular resistance. The latter indicates greatly augmented renal vasoconstriction or more precisely reduction in intrarenal vasodilatation by inhibition of vasodilatory prostaglandin (PG) synthesis. Urine volume decreased. The 12-week-old young adult animals responded in a similar, but significantly attenuated fashion. These experiments demonstrate that inhibition of PG synthesis in neonatal animals causes very rapid, reversible vasoconstriction, with a reduction in GFR. In addition, this study confirms previous observations that the renal hemodynamic response to the inhibition of PG synthesis is far more pronounced in neonatal animals than in (young) adult rabbits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:39:12