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Titolo:
Positron emission tomography of dopamine pathways in familial Parkinsoniansyndromes
Autore:
Pal, PK; Wszolek, ZK; Uitti, R; Markopoulou, K; Calne, SM; Stoessl, AJ; Calne, DB;
Indirizzi:
Vancouver Hosp & Hlth Sci Ctr, Neurodegenerat Disorders Ctr, Vancouver, BCV6T 2B5, Canada Vancouver Hosp & Hlth Sci Ctr Vancouver BC Canada V6T 2B5 V6T 2B5, Canada NIMHANS, Bangalore, Karnataka, India NIMHANS Bangalore Karnataka IndiaNIMHANS, Bangalore, Karnataka, India Nebraska Med Ctr, Neurol Sect, Omaha, NE USA Nebraska Med Ctr Omaha NE USA braska Med Ctr, Neurol Sect, Omaha, NE USA Mayo Clin, Jacksonville, FL USA Mayo Clin Jacksonville FL USAMayo Clin, Jacksonville, FL USA
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 1, volume: 8, anno: 2001,
pagine: 51 - 56
SICI:
1353-8020(200109)8:1<51:PETODP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PONTO-NIGRAL DEGENERATION; AUTOSOMAL-DOMINANT PARKINSONISM; PROGRESSIVE SUPRANUCLEAR PALSY; ALPHA-SYNUCLEIN GENE; IDIOPATHIC PARKINSONISM; C-11 RACLOPRIDE; DISEASE; PET; DEMENTIA; MUTATION;
Keywords:
PET; Parkinsonism; familial; genetic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Calne, DB Vancouver Hosp & Hlth Sci Ctr, Neurodegenerat Disorders Ctr, Purdy Pavill,2221 Westbrook Mall, Vancouver, BC V6T 2B5, Canada Vancouver Hosp& Hlth Sci Ctr Purdy Pavill,2221 Westbrook Mall Vancouver BC Canada V6T 2B5
Citazione:
P.K. Pal et al., "Positron emission tomography of dopamine pathways in familial Parkinsoniansyndromes", PARKINS R D, 8(1), 2001, pp. 51-56

Abstract

Positron emission tomography (PET) scan is considered to be the most useful tool with which to assess the integrity of nigrostriatal function in the living brain. Recently, different genetic defects have been associated witha variety of familial parkinsonian syndromes, the clinical phenotypes of which have varying degrees of similarities to idiopathic parkinsonism (IP), (sporadic Parkinson's disease). This review summarizes: (1) the PET scan findings (fluorodopa uptake and raclopride binding) in both familial parkinsonian syndromes and IP; and (2) the similarities and differences of the clinical and PET features between familial parkinsonian syndromes and IP. This analysis demonstrates that more similarities than differences exist in PET scan findings in the different familial parkinsonian syndromes with the exception of pallido-ponto-nigral degeneration (PPND), that is perhaps best considered as multisystem degeneration. As a result of this analysis, we believe that while different genetic defects may underlie different mechanisms of nigrostriatal degeneration, the final pattern of nigrostriatal dysfunction is essentially similar to that of IP. 'Parkinson's disease', therefore, may not represent a single disease entity, but rather the final manifestation of different pathogenetic mechanisms-mediated by genetic or environmental factors, or an interaction of genetic and environmental factors. (C) 2001Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 19:15:47