Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CSF-neurofilament and levodopa tests combined with discriminant analysis may contribute to the differential diagnosis of Parkinsonian syndromes
Autore:
Holmberg, B; Johnels, B; Ingvarsson, P; Eriksson, B; Rosengren, L;
Indirizzi:
Gothenburg Univ, Sahlgrens Hosp, Dept Neurol, Inst Clin Neurosci, S-41345 Gothenburg, Sweden Gothenburg Univ Gothenburg Sweden S-41345 ci, S-41345 Gothenburg, Sweden
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 1, volume: 8, anno: 2001,
pagine: 23 - 31
SICI:
1353-8020(200109)8:1<23:CALTCW>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-SYSTEM ATROPHY; PROGRESSIVE SUPRANUCLEAR PALSY; CORE ASSESSMENT PROGRAM; DOPAMINERGIC RESPONSE; CEREBROSPINAL-FLUID; CLINICAL-FEATURES; DISEASE; PROTEIN; CHALLENGE; SCLEROSIS;
Keywords:
Parkinson' disease; multiple system atrophy; progressive supranuclear palsy; differential diagnosis; levodopa tests; neurofilament protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Holmberg, B Gothenburg Univ, Sahlgrens Hosp, Dept Neurol, Inst Clin Neurosci, S-41345 Gothenburg, Sweden Gothenburg Univ Gothenburg Sweden S-41345 Gothenburg, Sweden
Citazione:
B. Holmberg et al., "CSF-neurofilament and levodopa tests combined with discriminant analysis may contribute to the differential diagnosis of Parkinsonian syndromes", PARKINS R D, 8(1), 2001, pp. 23-31

Abstract

The differentiation between Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) is important for prognostic and therapeutic purposes. In order to evaluate the diagnostic capability of two tests reflecting these items, patients fulfilling strict clinical criteria for PD (n = 35), MSA (n = 36) and PSP (n = 14), were consecutivelyincluded. An analysis of neurofilament protein (NFL), a marker of axonal degeneration in the cerebrospinal fluid (CSF) and a levodopa test, recorded with optoelectronic technique were performed. Using discriminant analyses, the test's abilities to predict the clinical PD or non-PD (MSA and PSP) diagnoses were compared. Whereas the CSF-NFL and levodopa tests predicted 79 and 85% correct diagnoses respectively, the combined test predicted 90% correct diagnoses. We conclude that the CSF-NFL and levodopa tests provide detailed information of clinical variables on which the clinical diagnostic criteria are based. As they are pathologically unrelated, the diagnostic precision increases compared to clinical diagnoses when they are combined. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:56:28