Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The parkinsonian neurotoxin, MPP+ induces phosphorylated c-Jun in dopaminergric neurons of mesencephalic cultures
Autore:
Gearan, T; Castillo, OA; Schwarzschild, MA;
Indirizzi:
Massachusetts Gen Hosp, Dept Neurol, Mol Neurobiol Lab, Charlestown, MA 02129 USA Massachusetts Gen Hosp Charlestown MA USA 02129 Charlestown, MA 02129 USA
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 1, volume: 8, anno: 2001,
pagine: 19 - 22
SICI:
1353-8020(200109)8:1<19:TPNMIP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANTIA-NIGRA; ACTIVATION; APOPTOSIS; JNK; KINASES; EXPRESSION; DEATH;
Keywords:
stress-activated protein kinase; c-Jun N-terminal kinase; apoptosis; 1-methyl-4-phenylpyridinium; ventral mesencephalon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Schwarzschild, MA Massachusetts Gen Hosp, Dept Neurol, Mol Neurobiol Lab, CNY 6616,Bldg 149 13th St, Charlestown, MA 02129 USA Massachusetts Gen HospCNY 6616,Bldg 149 13th St Charlestown MA USA 02129
Citazione:
T. Gearan et al., "The parkinsonian neurotoxin, MPP+ induces phosphorylated c-Jun in dopaminergric neurons of mesencephalic cultures", PARKINS R D, 8(1), 2001, pp. 19-22

Abstract

The stress-activated protein kinase (SAPK) cascade serves a critical role in the apoptotic death of neuronal cells in response to a variety of cellular stresses. Recent in vitro and in vivo evidence has directly implicated this kinase in the death of dopaminergic nigral neurons in the MPTP model ofParkinson's disease (PD). To assess the involvement of c-Jun, a key transcription factor substrate of SAPK (also known as c-Jun N-terminal kinase, orJNK) in the MPTP-induced death of dopaminergic nigral neurons, we determined the ability of MPP+, the active toxin metabolite of MPTP, to induce the phosphorylated form of c-Jun in dopaminergic neurons in nigral (ventral mesencephalon) cultures. At a dose of MPP+ that specifically induces apoptoticchanges in nuclear morphology in tyrosine hydroxylase-positive (dopaminergic) cells in these cultures, MPP+ induces nuclear phospho-c-Jun immunoreactivity (IR). The peak induction of phospho-c-Jun IR was observed 16 h after beginning MPP+ exposure, and preceded the maximal induction of apoptotic nuclear changes by approximately 8 h. These data support an important role for the SAPK/JNK pathway including its c-Jun transcriptional target in the apoptotic death of dopaminergic nigral neurons in the MPTP model of PD. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:20:07