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Titolo:
The long-term response to levodopa in dopa-responsive dystonia
Autore:
Hwang, WJ; Calne, DB; Tsui, JKC; de la Fuente-Fernandez, R;
Indirizzi:
Vancouver Hosp & Hlth Sci Ctr, Neurodegenerat Disorders Ctr, Vancouver, BCV5Z 1M9, Canada Vancouver Hosp & Hlth Sci Ctr Vancouver BC Canada V5Z 1M9 V5Z 1M9, Canada
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 1, volume: 8, anno: 2001,
pagine: 1 - 5
SICI:
1353-8020(200109)8:1<1:TLRTLI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MARKED DIURNAL FLUCTUATION; CYCLOHYDROLASE-I GENE; PROGRESSIVE DYSTONIA; PARKINSONISM; DYSKINESIA; FAMILY; ONSET;
Keywords:
dopa-responsive dystonia; levodopa; dyskinesia; dopamine turnover;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: de la Fuente-Fernandez, R Vancouver Hosp & Hlth Sci Ctr, Neurodegenerat Disorders Ctr, Vancouver, BCV5Z 1M9, Canada Vancouver Hosp & Hlth Sci Ctr Vancouver BC Canada V5Z 1M9
Citazione:
W.J. Hwang et al., "The long-term response to levodopa in dopa-responsive dystonia", PARKINS R D, 8(1), 2001, pp. 1-5

Abstract

We report the long-term response to levodopa in 20 patients with dopa-responsive dystonia (DRD). We found an inverse correlation between the daily dose of levodopa and duration of treatment (r = -0.59, P < 0.01). Mild dyskinesias were present in 20% of our patients. Dyskinetic patients were on a higher dose of levodopa than non-dyskinetics. Dyskinesias responded to a reduction in levodopa, with no deterioration in motor function. We propose thatthe dopamine turnover might decrease with time, which would lead to a decrease in the requirement for levodopa and the occurrence of dyskinesias latein the course of DRD. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:11:07