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Titolo:
Changes in bone density in patients with ankylosing spondylitis: A two-year follow-up study
Autore:
Maillefert, JF; Aho, LS; El Maghraoui, A; Dougados, M; Roux, C;
Indirizzi:
Univ Paris 05, Dept Rheumatol, Cochin Hosp, F-75679 Paris 14, France Univ Paris 05 Paris France 14 tol, Cochin Hosp, F-75679 Paris 14, France Dijon Univ Hosp, Dept Epidemiol, Dijon, France Dijon Univ Hosp Dijon France n Univ Hosp, Dept Epidemiol, Dijon, France Dijon Univ Hosp, Dept Rheumatol, Dijon, France Dijon Univ Hosp Dijon France n Univ Hosp, Dept Rheumatol, Dijon, France
Titolo Testata:
OSTEOPOROSIS INTERNATIONAL
fascicolo: 7, volume: 12, anno: 2001,
pagine: 605 - 609
SICI:
0937-941X(2001)12:7<605:CIBDIP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINERAL DENSITY; DISEASE-ACTIVITY; VERTEBRAL FRACTURES; OSTEOPOROSIS; MASS; INDEX; BATH; PREVALENCE; TURNOVER; SCORE;
Keywords:
ankylosing spondylitis; bone mineral density; C-reactive protein; erythrocyte sedimentation rate; osteoporosis; systemic inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Roux, C Univ Paris 05, Dept Rheumatol, Cochin Hosp, 27 Rue Fb St Jacques, F-75679 Paris 14, France Univ Paris 05 27 Rue Fb St Jacques Paris France 14 ris 14, France
Citazione:
J.F. Maillefert et al., "Changes in bone density in patients with ankylosing spondylitis: A two-year follow-up study", OSTEOPOR IN, 12(7), 2001, pp. 605-609

Abstract

The objectives of the study were to determine the 2 year rate of bone changes in patients with ankylosing spondylitis (AS) and, whether bone loss is related to physical impairment, systemic inflammation, and therapy. Consecutive outpatients fulfulling the modified New York criteria for AS were included. Baseline assessment included age, disease duration, treatment, clinical, radiologic and laboratory data. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were determined every 6 months. Persistent systemic inflammation was defined as mean ESR greater than or equal to 28 mm/h or mean CRP greater than or equal to 15 mg/l. Bone mineral density (BMD) at the lumbar spine and femoral neck was measured by dual-energy X-ray absorptiometry, at baseline and year 2. Statistical analysis compared the baselineand 24 month follow-up BMD data, and determined whether baseline data, andpersistent systemic inflammation during the 2 years, were related to the 24 month percentage changes in BMD. Fifty-four patients (35 men, 19 women; mean age 37.3 +/- 11.3 years, mean disease duration 12.4 +/- 8.6 years) wereincluded. After 2 years, BMD did not change at the lumbar spine (+0.75% +/- 3.5, p = 0.23), and decreased at the femoral neck (-1.6% +/- 4, p = 0.006). The 24 month percentage change in femoral neck BMD was related to persistent systemic inflammation, defined using ESR (mean percentage change -4.1%+/- 5.7 and - 1.2% +/- 3.9 in patients with and without persistent inflammation; respectively; p = 0.007). These results suggest that persistent inflammation might be an etiologic factor of bone loss in AS.

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Documento generato il 30/10/20 alle ore 23:39:42