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Titolo:
A comparative study of computed digital absorptiometry and conventional dual-energy X-ray absorptiometry in postmenopausal women
Autore:
Fiter, J; Nolla, JM; Gomez-Vaquero, C; Martinez-Aguila, D; Valverde, J; Roig-Escofet, D;
Indirizzi:
Ciutat Sanitaria & Univ Bellvitge, Rheumatol Serv, Barcelona 08907, Spain Ciutat Sanitaria & Univ Bellvitge Barcelona Spain 08907 ona 08907, Spain
Titolo Testata:
OSTEOPOROSIS INTERNATIONAL
fascicolo: 7, volume: 12, anno: 2001,
pagine: 565 - 569
SICI:
0937-941X(2001)12:7<565:ACSOCD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHALANGEAL BONE-DENSITY; RADIOGRAPHIC ABSORPTIOMETRY; QUANTITATIVE ULTRASOUND; MINERAL DENSITY; HIP-FRACTURES; LUMBAR SPINE; OSTEOPOROSIS; DENSITOMETRY; CLASSIFICATION; MANAGEMENT;
Keywords:
computed digital absorptiometry; dual-energy X-ray absorptiometry; osteoporosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Fiter, J Ciutat Sanitaria & Univ Bellvitge, Rheumatol Serv, Feixa Llarga S-N, Barcelona 08907, Spain Ciutat Sanitaria & Univ Bellvitge Feixa Llarga S-N Barcelona Spain 08907
Citazione:
J. Fiter et al., "A comparative study of computed digital absorptiometry and conventional dual-energy X-ray absorptiometry in postmenopausal women", OSTEOPOR IN, 12(7), 2001, pp. 565-569

Abstract

The aim of the study was to evaluate whether computed digital absorptiometry (CDA) of the hand might be a useful screening technique for identifying patients with postmenopausal osteoporosis and to compare the results of CDAwith those of dual-energy X-ray absorptiometry (DXA) of the lumbar spine and femoral neck. We studied 230 postmenopausal women (mean age 58.4 +/- 7.9years). For CDA, bone mineral density (BMD) was measured with an AccuDEXA Schick densitometer in the third middle phalanx of the nondominant hand. For DXA, BMD of the lumbar spine and upper femur was assessed using a DXA Hologic QDR-1000 densitometer. We did a comparative analysis (ANOVA) and linear correlation tests. Sensitivity and specificity of CDA and receiver operating characteristic (ROC) curves for the diagnosis of osteoporosis were calculated. The mean BMD with CDA was 0.445 +/- 0.084 (T-score: - 1.27 +/- 1.29). The mean BMD (g/cm(2)) with DXA at the lumbar spine was 0.877 +/- 0. 166(T-score: - 1.52 +/- 1.59) and 0.708 +/- 0.127 at the femoral neck (T-score: -1.12 +/- 1.25). BMD at the lumbar spine and femoral neck correlated positively with CDA of the hand (r = 0.66 and r = 0.65 respectively, p <0.001). When using as cut-off a T-score of -2.5, according to WHO criteria, 76 women (33%) had osteoporosis of the lumbar spine and/or femoral neck with DXAand 42 (18%) with CDA (p <0.001). The kappa score for osteoporosis was 0.33 for CDA versus spinal DXA and 0.35 for CDA versus femoral DXA. With the cut-off level used, sensitivity and specificity of CDA in detecting osteoporosis at the lumbar spine were 0.39 and 0.90, respectively; sensitivity and specificity of CDA in identifying osteoporosis at the femoral neck were 0.58 and 0.87, respectively. The positive predictive value of CDA for osteoporosis. was 69% and the negative predictive value was 75%. The area under theROC curve for osteoporosis was 0.822 +/- 0.028. We conclude that: (a) CDA assessment has a moderate correlation with BMD measured by DXA at the lumbar spine and femoral neck; (b) CDA has a low sensitivity for the diagnosis of osteoporosis compared with spinal and femoral DXA; and (c) predictive values for osteoporosis at both the lumbar spine and femoral neck are acceptable.

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Documento generato il 29/02/20 alle ore 13:25:07