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Titolo:
Synthesis and NMR-analysis of tricyclic nucleosides
Autore:
Nielsen, P; Petersen, M; Jacobsen, JP;
Indirizzi:
Univ So Denmark, Dept Chem, DK-5230 Odense M, Denmark Univ So Denmark Odense Denmark M k, Dept Chem, DK-5230 Odense M, Denmark
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4-7, volume: 20, anno: 2001,
pagine: 1309 - 1312
SICI:
1525-7770(2001)20:4-7<1309:SANOTN>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARABINONUCLEIC ACIDS; PAIRING PROPERTIES; RNA; AFFINITY; BACKBONE; ANALOGS; HYBRIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Nielsen, P Univ So Denmark, Dept Chem, DK-5230 Odense M, Denmark Univ So Denmark Odense Denmark M m, DK-5230 Odense M, Denmark
Citazione:
P. Nielsen et al., "Synthesis and NMR-analysis of tricyclic nucleosides", NUCLEOS NUC, 20(4-7), 2001, pp. 1309-1312

Abstract

Two anomeric tricyclic nucleosides have been synthesised from diacetone-D-glucose using oxidation, stereoselective Grignard-addition of a vinyl-group, a stereoselective dihydroxylation followed by a tandem ring closing reaction, and finally a nucleobase coupling. The main beta -configured product was examined and its configuration confirmed using NMR-spectroscopy in connection to ab initio calculations. The preferred conformation of this tricyclic nucleoside was described.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:31:14