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Titolo:
Inhibition of human telomerase by L-enantiomers of natural 2 '-deoxyribonucleoside 5 '-triphosphates
Autore:
Yamaguchi, T; Yamada, R; Tomikawa, A; Shudo, K; Saito, M; Ishikawa, F; Saneyoshi, M;
Indirizzi:
Teikyo Univ Sci & Technol, Dept Biol Sci, Yamanashi 4090193, Japan Teikyo Univ Sci & Technol Yamanashi Japan 4090193 manashi 4090193, Japan Teikyo Univ Sci & Technol, Biotechnol Res Ctr, Yamanashi 4090193, Japan Teikyo Univ Sci & Technol Yamanashi Japan 4090193 manashi 4090193, Japan Natl Inst Hlth Sci, Setagaya Ku, Tokyo 1588501, Japan Natl Inst Hlth Sci Tokyo Japan 1588501 Setagaya Ku, Tokyo 1588501, Japan Tokyo Inst Technol, Dept Life Sci, Midori Ku, Yokohama, Kanagawa 2268501, Japan Tokyo Inst Technol Yokohama Kanagawa Japan 2268501 anagawa 2268501, Japan
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4-7, volume: 20, anno: 2001,
pagine: 1243 - 1246
SICI:
1525-7770(2001)20:4-7<1243:IOHTBL>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
REVERSE-TRANSCRIPTASE; CHIRAL DISCRIMINATION; NUCLEOTIDES; ANALOGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Yamaguchi, T Teikyo Univ Sci & Technol, Dept Biol Sci, Yamanashi 4090193, Japan Teikyo Univ Sci & Technol Yamanashi Japan 4090193 93, Japan
Citazione:
T. Yamaguchi et al., "Inhibition of human telomerase by L-enantiomers of natural 2 '-deoxyribonucleoside 5 '-triphosphates", NUCLEOS NUC, 20(4-7), 2001, pp. 1243-1246

Abstract

In order to clarify whether L-enantiomers of natural 2'-deoxyribonucleoside 5'-triphosphates (dNTPs) are recognized by human telomerase, a quantitative telomerase assay based on the 'stretch PCR' method was developed and used for kinetic analysis. Among the four L-dNTPs, L-dTTP and L-dGTP inhibitedtelomerase activity and the others showed slight or no inhibitory effect. Lineweaver-Burk plot analysis showed that the inhibition mode L-dGTP was competitive with dGTP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:30:20